Drug Detail


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Drug Name Ripretinib
Trade Name Qinlock
Synonyms DCC-2618|DCC2618
Drug Descriptions

Qinlock (ripretinib) is a dual inhibitor of KIT and PDGFRa, resulting in growth inhibition and anti-tumor effects (PMID: 29439183, PMID: 31085175, PMID: 31201392). Qinlock (ripretinib) is FDA approved for use in patients with advanced gastrointestinal stromal tumor who received 3 or more prior kinase inhibitor therapies (FDA.gov)

DrugClasses KIT Inhibitor 57 PDGFR-alpha Inhibitor 9
CAS Registry Number 1442472-39-0
NCIT ID C124067


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Binimetinib + Ripretinib Binimetinib Ripretinib 0 1
DCC-3116 + Ripretinib DCC-3116 Ripretinib 0 1
Repaglinide + Ripretinib Repaglinide Ripretinib 0 1
Ripretinib Ripretinib 79 4
Ripretinib + Sunitinib Ripretinib Sunitinib 5 0
Ripretinib + Trametinib Ripretinib Trametinib 0 0

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