Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Ulixertinib
Trade Name
Synonyms BVD-523|BVD 523|BVD523
Drug Descriptions

Ulixertinib (BVD-523) inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways and resulting in growth inhibition (PMID: 28939558).

DrugClasses ERK Inhibitor (pan) 21
CAS Registry Number 869886-67-9
NCIT ID C104744


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
AZD8186 + Ulixertinib AZD8186 Ulixertinib 0 0
Binimetinib + Ulixertinib Binimetinib Ulixertinib 1 0
Cetuximab + Encorafenib + Ulixertinib Cetuximab Encorafenib Ulixertinib 1 1
Cetuximab + Ulixertinib Cetuximab Ulixertinib 0 1
Gemcitabine + Nab-paclitaxel + Ulixertinib Gemcitabine Nab-paclitaxel Ulixertinib 0 1
Hydroxychloroquine + Ulixertinib Hydroxychloroquine Ulixertinib 0 2
JQ1 + Ulixertinib JQ1 Ulixertinib 1 0
Lifirafenib + Ulixertinib Lifirafenib Ulixertinib 2 0
MRTX-1133 + Ulixertinib MRTX-1133 Ulixertinib 0 0
Navitoclax + Ulixertinib Navitoclax Ulixertinib 1 0
Palbociclib + Ulixertinib Palbociclib Ulixertinib 1 1
Repotrectinib + Ulixertinib Repotrectinib Ulixertinib 0 0
Selpercatinib + Ulixertinib Selpercatinib Ulixertinib 0 0
Selumetinib + Ulixertinib Selumetinib Ulixertinib 1 0
SHP099 + Ulixertinib SHP099 Ulixertinib 1 0
Tipifarnib + Ulixertinib Tipifarnib Ulixertinib 2 0
Trametinib + Ulixertinib Trametinib Ulixertinib 1 0
Ulixertinib Ulixertinib 31 8
Ulixertinib + Vinblastine Ulixertinib Vinblastine 1 0

Additional content available in CKB BOOST