Drug Detail


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Drug Name Ulixertinib
Trade Name
Synonyms BVD-523|BVD 523|BVD523
Drug Descriptions

Ulixertinib (BVD-523) inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways and resulting in growth inhibition (PMID: 28939558).

DrugClasses ERK Inhibitor (pan) 17
CAS Registry Number 869886-67-9
NCIT ID C104744


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Therapy Name Drugs Efficacy Evidence Clinical Trials
AZD8186 + Ulixertinib AZD8186 Ulixertinib 0 0
BGB-283 + Ulixertinib BGB-283 Ulixertinib 2 0
Gemcitabine + Nab-paclitaxel + Ulixertinib Gemcitabine Nab-paclitaxel Ulixertinib 0 1
Hydroxychloroquine + Ulixertinib Hydroxychloroquine Ulixertinib 0 2
JQ1 + Ulixertinib JQ1 Ulixertinib 1 0
Palbociclib + Ulixertinib Palbociclib Ulixertinib 1 1
SHP099 + Ulixertinib SHP099 Ulixertinib 1 0
Tipifarnib + Ulixertinib Tipifarnib Ulixertinib 2 0
Trametinib + Ulixertinib Trametinib Ulixertinib 0 0
Ulixertinib Ulixertinib 17 8

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