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Drug Name Tipifarnib
Trade Name
Synonyms Zarnestra|R115777
Drug Descriptions

Zarnestra (tipifarnib) is a farnesyltransferase inhibitor, which alters post-translational modification and activation of Ras proteins, and may result in decreased tumor cell proliferation and reduced tumor growth (PMID: 11196150, PMID: 25323927, PMID: 32557577).

DrugClasses Farnesyltransferase Inhibitor 4
CAS Registry Number 192185-72-1


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Adagrasib + Tipifarnib Adagrasib Tipifarnib 0 0
Alpelisib + Tipifarnib Alpelisib Tipifarnib 11 1
AZD8186 + Tipifarnib AZD8186 Tipifarnib 1 0
Osimertinib + Tipifarnib Osimertinib Tipifarnib 0 1
Sapanisertib + Tipifarnib Sapanisertib Tipifarnib 1 0
SCH772984 + Tipifarnib SCH772984 Tipifarnib 2 0
Sotorasib + Tipifarnib Sotorasib Tipifarnib 0 0
Tipifarnib Tipifarnib 23 8
Tipifarnib + Ulixertinib Tipifarnib Ulixertinib 2 0
Tipifarnib + Uprosertib Tipifarnib Uprosertib 1 0

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