Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Tipifarnib
Trade Name
Synonyms Zarnestra|R115777
Drug Descriptions

Zarnestra (tipifarnib) is a farnesyltransferase inhibitor, which alters post-translational modification and activation of Ras proteins, and may result in decreased tumor cell proliferation and reduced tumor growth (PMID: 11196150, PMID: 25323927, PMID: 32557577).

DrugClasses Farnesyltransferase Inhibitor 4
CAS Registry Number 192185-72-1
NCIT ID C1703

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Adagrasib + Tipifarnib Adagrasib Tipifarnib 0 0
Alpelisib + Tipifarnib Alpelisib Tipifarnib 11 1
AZD8186 + Tipifarnib AZD8186 Tipifarnib 1 0
Osimertinib + Tipifarnib Osimertinib Tipifarnib 0 1
Sapanisertib + Tipifarnib Sapanisertib Tipifarnib 1 0
SCH772984 + Tipifarnib SCH772984 Tipifarnib 2 0
Sotorasib + Tipifarnib Sotorasib Tipifarnib 0 0
Tipifarnib Tipifarnib 23 8
Tipifarnib + Ulixertinib Tipifarnib Ulixertinib 2 0
Tipifarnib + Uprosertib Tipifarnib Uprosertib 1 0


Additional content available in CKB BOOST