Drug Detail


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Drug Name AZD8186
Trade Name
Synonyms AZD-8186|AZD 8186
Drug Descriptions

AZD8186 selectively inhibits the activity of PI3Kbeta (PIK3CB) and delta (PIK3CD) in the PI3K/Akt/mTOR signaling pathway, which may result in decreased tumor cell proliferation (PMID: 25514658, PMID: 32194423).

DrugClasses PIK3CB inhibitor 8 PIK3CD inhibitor 27
CAS Registry Number 1296270-45-5
NCIT ID C107684


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + AZD8186 AZD8186 Abiraterone 0 1
Abiraterone + AZD8186 + Prednisone AZD8186 Abiraterone Prednisone 0 0
Alpelisib + AZD8186 AZD8186 Alpelisib 2 0
Alpelisib + AZD8186 + Enzalutamide AZD8186 Alpelisib Enzalutamide 1 0
AZD5991 + AZD8186 AZD5991 AZD8186 1 0
AZD8186 AZD8186 5 1
AZD8186 + Docetaxel AZD8186 Docetaxel 0 1
AZD8186 + Enzalutamide AZD8186 Enzalutamide 1 0
AZD8186 + SCH772984 AZD8186 SCH772984 0 0
AZD8186 + Tipifarnib AZD8186 Tipifarnib 1 0
AZD8186 + Ulixertinib AZD8186 Ulixertinib 0 0
AZD8186 + Vistusertib AZD8186 Vistusertib 1 1

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