Therapy Detail

Therapy Name AZD8186 + Vistusertib
Synonym
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AZD8186 PIK3CB inhibitor 8 PIK3CD inhibitor 24 AZD8186 selectively inhibits the activity of PI3Kbeta (PIK3CB) and delta (PIK3CD) in the PI3K/Akt/mTOR signaling pathway, which may result in decreased tumor cell proliferation (PMID: 25514658).
Vistusertib AZD2014 mTOR Inhibitor 48 Vistusertib (AZD2014) inhibits the activity of mTOR, which may result in tumor growth inhibition (PMID: 23375793).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PTEN loss colorectal cancer sensitive AZD8186 + Vistusertib Phase I Actionable In a Phase I trial, the combination of AZD8186 and Vistusertib (AZD2014) resulted in a partial response in a patient with PTEN-deficient colorectal cancer (J Clin Oncol 35, 2017 (suppl; abstr 2570)). detail...
Unknown unknown prostate cancer not applicable AZD8186 + Vistusertib Phase I Actionable In a Phase I trial, the combination of AZD8186 and Vistusertib (AZD2014) resulted in a partial response in a patient with castration resistant prostate cancer (J Clin Oncol 35, 2017 (suppl; abstr 2570)). detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT01884285 Phase I AZD8186 Abiraterone + AZD8186 AZD8186 + Vistusertib AZD8186 First Time In Patient Ascending Dose Study Recruiting