Drug Detail


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Drug Name SHP099
Trade Name
Synonyms SHP-099|SHP 099
Drug Descriptions

SHP099 is an allosteric inhibitor of SHP2 that stabilizes SHP2 in its autoinhibited conformation, which reduces downstream signaling and potentially leads to decreased growth of receptor tyrosine kinase-driven tumors (PMID: 27362227, PMID: 31043123).

DrugClasses SHP2 Inhibitor 18
CAS Registry Number 1801747-42-4


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Alectinib + SHP099 Alectinib SHP099 1 0
AZD4625 + SHP099 AZD4625 SHP099 0 0
Crizotinib + SHP099 Crizotinib SHP099 0 0
Fulvestrant + Palbociclib + SHP099 Fulvestrant Palbociclib SHP099 0 0
Fulvestrant + Palbociclib + SHP099 + Trametinib Fulvestrant Palbociclib SHP099 Trametinib 0 0
Fulvestrant + SHP099 Fulvestrant SHP099 0 0
Fulvestrant + SHP099 + Trametinib Fulvestrant SHP099 Trametinib 0 0
Osimertinib + SHP099 Osimertinib SHP099 0 0
Selumetinib + SHP099 SHP099 Selumetinib 0 0
SHP099 SHP099 9 0
SHP099 + Taletrectinib SHP099 Taletrectinib 0 0
SHP099 + Trametinib SHP099 Trametinib 1 0
SHP099 + Ulixertinib SHP099 Ulixertinib 1 0
SHP099 + Vemurafenib SHP099 Vemurafenib 1 0

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