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Drug Name | SHP099 |
Trade Name | |
Synonyms | SHP-099|SHP 099 |
Drug Descriptions |
SHP099 is an allosteric inhibitor of SHP2 that stabilizes SHP2 in its autoinhibited conformation, which reduces downstream signaling and potentially leads to decreased growth of receptor tyrosine kinase-driven tumors (PMID: 27362227, PMID: 31043123). |
DrugClasses | SHP2 Inhibitor 14 |
CAS Registry Number | 1801747-42-4 |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Alectinib + SHP099 | Alectinib SHP099 | 1 | 0 |
Crizotinib + SHP099 | Crizotinib SHP099 | 0 | 0 |
DS6051b + SHP099 | DS6051b SHP099 | 0 | 0 |
Fulvestrant + Palbociclib + SHP099 | Fulvestrant Palbociclib SHP099 | 0 | 0 |
Fulvestrant + Palbociclib + SHP099 + Trametinib | Fulvestrant Palbociclib SHP099 Trametinib | 0 | 0 |
Fulvestrant + SHP099 | Fulvestrant SHP099 | 0 | 0 |
Fulvestrant + SHP099 + Trametinib | Fulvestrant SHP099 Trametinib | 0 | 0 |
Osimertinib + SHP099 | Osimertinib SHP099 | 0 | 0 |
Selumetinib + SHP099 | SHP099 Selumetinib | 0 | 0 |
SHP099 | SHP099 | 9 | 0 |
SHP099 + Trametinib | SHP099 Trametinib | 1 | 0 |
SHP099 + Ulixertinib | SHP099 Ulixertinib | 1 | 0 |
SHP099 + Vemurafenib | SHP099 Vemurafenib | 1 | 0 |