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Drug Name Repotrectinib
Trade Name Augtyro
Synonyms TPX-0005
Drug Descriptions

Augtyro (repotrectinib) is a multi-kinase inhibitor that demonstrates strong activity against Ros1, Ntrk1/2/3, and Alk, and also inhibits Jak2 and Src family kinases, resulting in tumor cell death (PMID: 30093503, PMID: 32269053). Augtyro (repotrectinib) is FDA-approved for use in patients with advanced or metastatic ROS1 fusion-positive non-small cell lung cancer (FDA.gov).

DrugClasses ALK Inhibitor 32 JAK2 Inhibitor 17 ROS1 Inhibitor 20 SRC Inhibitor 31 Trk Receptor Inhibitor (Pan) 31
CAS Registry Number 1802220-02-5
NCIT ID C133821


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Fulvestrant + Repotrectinib Fulvestrant Repotrectinib 0 1
Gefitinib + Repotrectinib + Trametinib Gefitinib Repotrectinib Trametinib 0 0
Irinotecan + Repotrectinib + Temozolomide Irinotecan Repotrectinib Temozolomide 1 1
Osimertinib + Repotrectinib Osimertinib Repotrectinib 0 1
Repotrectinib Repotrectinib 32 4
Repotrectinib + SCH772984 Repotrectinib SCH772984 0 0
Repotrectinib + Sotorasib Repotrectinib Sotorasib 0 0
Repotrectinib + Trametinib Repotrectinib Trametinib 0 1
Repotrectinib + Ulixertinib Repotrectinib Ulixertinib 0 0

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