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Drug Name | Repotrectinib |
Trade Name | |
Synonyms | TPX-0005 |
Drug Descriptions |
Repotrectinib (TPX-0005) is a multi-kinase inhibitor that demonstrates strong activity against Ros1, Ntrk1/2/3, and Alk, and also inhibits Jak2 and Src family kinases, resulting in tumor cell death (PMID: 30093503, PMID: 32269053). |
DrugClasses | ALK Inhibitor 31 JAK2 Inhibitor 16 ROS1 Inhibitor 20 SRC Inhibitor 31 Trk Receptor Inhibitor (Pan) 31 |
CAS Registry Number | 1802220-02-5 |
NCIT ID | C133821 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Irinotecan + Repotrectinib + Temozolomide | Irinotecan Repotrectinib Temozolomide | 1 | 1 |
Osimertinib + Repotrectinib | Osimertinib Repotrectinib | 0 | 1 |
Repotrectinib | Repotrectinib | 24 | 2 |
Repotrectinib + SCH772984 | Repotrectinib SCH772984 | 0 | 0 |
Repotrectinib + Sotorasib | Repotrectinib Sotorasib | 0 | 0 |
Repotrectinib + Trametinib | Repotrectinib Trametinib | 0 | 1 |
Repotrectinib + Ulixertinib | Repotrectinib Ulixertinib | 0 | 0 |