Drug Detail


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Drug Name Repotrectinib
Trade Name
Synonyms TPX-0005
Drug Descriptions

Repotrectinib (TPX-0005) is a multi-kinase inhibitor that demonstrates strong activity against Ros1, Ntrk1/2/3, and Alk, and also inhibits Jak2 and Src family kinases, resulting in tumor cell death (PMID: 30093503, PMID: 32269053).

DrugClasses ALK Inhibitor 29 JAK2 Inhibitor 16 ROS1 Inhibitor 19 SRC Inhibitor 31 Trk Receptor Inhibitor (Pan) 29
CAS Registry Number 1802220-02-5
NCIT ID C133821


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Irinotecan + Repotrectinib + Temozolomide Irinotecan Repotrectinib Temozolomide 0 1
Osimertinib + Repotrectinib Osimertinib Repotrectinib 0 1
Repotrectinib Repotrectinib 13 2
Repotrectinib + Sotorasib Repotrectinib Sotorasib 0 0
Repotrectinib + Trametinib Repotrectinib Trametinib 0 1

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