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Repotrectinib (TPX-0005) is a multi-kinase inhibitor that demonstrates strong activity against Ros1, Ntrk1/2/3, and Alk, and also inhibits Jak2 and Src family kinases, resulting in tumor cell death (PMID: 30093503, PMID: 32269053).
|DrugClasses||ALK Inhibitor 23 JAK2 Inhibitor 17 ROS1 Inhibitor 14 SRC Inhibitor 30 Trk Receptor Inhibitor (Pan) 24|
|CAS Registry Number||1802220-02-5|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|AMG 510 + Repotrectinib||AMG 510 Repotrectinib||0||0|