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Drug Name Selpercatinib
Trade Name Retevmo
Synonyms LOXO-292|LOXO292|LOXO 292|Retsevmo
Drug Descriptions

Retevmo (selpercatinib) is an inhibitor of RET that specifically targets RET mutations and fusions, and may block the growth of cells with increased Ret activity (PMID: 29860229). Retevmo (selpercatinib) is FDA approved for use in patients with locally advanced or metastatic non-small cell lung cancer harboring RET fusions, and in adult and pediatric patients of 12 years and older with RET-mutant medullary thyroid cancer or RET fusion-positive thyroid cancer refractory to radioactive iodine, and in patients with advanced or metastatic solid tumor harboring RET fusions (FDA.org).

DrugClasses RET Inhibitor 52
CAS Registry Number 2222755-14-6
NCIT ID C134987

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afatinib + Selpercatinib Afatinib Selpercatinib 0 0
Carboplatin + Pemetrexed Disodium + Selpercatinib Carboplatin Pemetrexed Disodium Selpercatinib 0 1
Crizotinib + Selpercatinib Crizotinib Selpercatinib 0 0
Dacomitinib + Selpercatinib Dacomitinib Selpercatinib 0 0
Dexamethasone + Selpercatinib Dexamethasone Selpercatinib 0 0
Entrectinib + Selpercatinib Entrectinib Selpercatinib 0 0
Erlotinib + Selpercatinib Erlotinib Selpercatinib 0 0
Larotrectinib + Selpercatinib Larotrectinib Selpercatinib 0 0
MitoQ + Selpercatinib MitoQ Selpercatinib 2 0
Osimertinib + Selpercatinib Osimertinib Selpercatinib 0 1
SCH772984 + Selpercatinib SCH772984 Selpercatinib 0 0
Selpercatinib Selpercatinib 87 11
Selpercatinib + Trametinib Selpercatinib Trametinib 0 0
Selpercatinib + Trastuzumab deruxtecan Selpercatinib Trastuzumab deruxtecan 0 0
Selpercatinib + Ulixertinib Selpercatinib Ulixertinib 0 0


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