Drug Detail


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Drug Name Selpercatinib
Trade Name Retevmo
Synonyms LOXO-292|LOXO292|LOXO 292
Drug Descriptions

Retevmo (selpercatinib) is an inhibitor of RET that specifically targets RET mutations and fusions, and may block the growth of cells with increased Ret activity (PMID: 29860229). Retevmo (selpercatinib) is FDA approved for use in patients with metastatic non-small cell lung cancer harboring RET fusions, and in adult and pediatric patient of 12 years and older with RET-mutant medullary thyroid cancer or RET fusion-positive thyroid cancer refractory to radioactive iodine (FDA.org).

DrugClasses RET Inhibitor 45
CAS Registry Number 2222755-14-6
NCIT ID C134987


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Crizotinib + Selpercatinib Crizotinib Selpercatinib 0 0
Dexamethasone + Selpercatinib Dexamethasone Selpercatinib 0 0
Larotrectinib + Selpercatinib Larotrectinib Selpercatinib 0 0
Osimertinib + Selpercatinib Osimertinib Selpercatinib 0 1
Selpercatinib Selpercatinib 35 9

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