Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
Drug Name | Entrectinib |
Trade Name | Rozlytrek |
Synonyms | RXDX-101 |
Drug Descriptions |
Rozlytrek (entrectinib) inhibits the activity of TrkA/B/C, Ros1 fusion proteins, and Alk, which leads to induction of apoptosis and inhibition of proliferation in cells expressing these kinases (PMID: 27003761). Rozlytrek (entrectinib) is FDA approved for use in patients with ROS1 positive non-small cell lung cancer and in adult and pediatric (1 year and older) patients with solid tumors harboring NTRK fusions without known acquired resistance mutations (FDA.gov). |
DrugClasses | ALK Inhibitor 32 ROS1 Inhibitor 20 Trk Receptor Inhibitor (Pan) 31 |
CAS Registry Number | 1108743-60-7 |
NCIT ID | C114984 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Adagrasib + Entrectinib | Adagrasib Entrectinib | 0 | 0 |
Afatinib + Entrectinib | Afatinib Entrectinib | 0 | 0 |
Capmatinib + Entrectinib | Capmatinib Entrectinib | 0 | 0 |
Decitabine and Cedazuridine + Entrectinib | Decitabine and Cedazuridine Entrectinib | 0 | 1 |
Entrectinib | Entrectinib | 54 | 20 |
Entrectinib + Goserelin | Entrectinib Goserelin | 0 | 1 |
Entrectinib + Letrozole | Entrectinib Letrozole | 0 | 1 |
Entrectinib + PAC-1 | Entrectinib PAC-1 | 0 | 1 |
Entrectinib + Selpercatinib | Entrectinib Selpercatinib | 0 | 0 |
Entrectinib + Selumetinib | Entrectinib Selumetinib | 0 | 0 |
Entrectinib + Sotorasib | Entrectinib Sotorasib | 0 | 0 |
Entrectinib + Tepotinib | Entrectinib Tepotinib | 0 | 0 |
Entrectinib + TNO155 | Entrectinib TNO155 | 0 | 0 |