Drug Detail


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Drug Name Entrectinib
Trade Name Rozlytrek
Synonyms RXDX-101
Drug Descriptions

Rozlytrek (entrectinib) inhibits the activity of TrkA/B/C, Ros1 fusion proteins, and Alk, which leads to induction of apoptosis and inhibition of proliferation in cells expressing these kinases (PMID: 27003761). Rozlytrek (entrectinib) is FDA approved for use in patients with ROS1 positive non-small cell lung cancer and in adult and pediatric (12 years and older) patients with solid tumors harboring NRTRK fusions without known acquired resistance mutations (FDA.gov).

DrugClasses ALK Inhibitor 23 ROS1 Inhibitor 14 Trk Receptor Inhibitor (Pan) 23


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Entrectinib Entrectinib 32 9

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