Drug Detail


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Drug Name Entrectinib
Trade Name Rozlytrek
Synonyms RXDX-101
Drug Descriptions

Rozlytrek (entrectinib) inhibits the activity of TrkA/B/C, Ros1 fusion proteins, and Alk, which leads to induction of apoptosis and inhibition of proliferation in cells expressing these kinases (PMID: 27003761). Rozlytrek (entrectinib) is FDA approved for use in patients with ROS1 positive non-small cell lung cancer and in adult and pediatric (1 year and older) patients with solid tumors harboring NTRK fusions without known acquired resistance mutations (FDA.gov).

DrugClasses ALK Inhibitor 32 ROS1 Inhibitor 20 Trk Receptor Inhibitor (Pan) 31
CAS Registry Number 1108743-60-7
NCIT ID C114984


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Adagrasib + Entrectinib Adagrasib Entrectinib 0 0
Afatinib + Entrectinib Afatinib Entrectinib 0 0
Brigatinib + Entrectinib Brigatinib Entrectinib 0 0
Capmatinib + Entrectinib Capmatinib Entrectinib 0 0
Decitabine and Cedazuridine + Entrectinib Decitabine and Cedazuridine Entrectinib 0 1
Entrectinib Entrectinib 54 20
Entrectinib + Goserelin Entrectinib Goserelin 0 1
Entrectinib + Letrozole Entrectinib Letrozole 0 1
Entrectinib + PAC-1 Entrectinib PAC-1 0 1
Entrectinib + Selpercatinib Entrectinib Selpercatinib 0 0
Entrectinib + Selumetinib Entrectinib Selumetinib 0 0
Entrectinib + Sotorasib Entrectinib Sotorasib 0 0
Entrectinib + Tepotinib Entrectinib Tepotinib 0 0
Entrectinib + TNO155 Entrectinib TNO155 0 0

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