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Drug Name Brigatinib
Trade Name Alunbrig
Synonyms AP26113
Drug Descriptions

Alunbrig (brigatinib) is a multi-kinase inhibitor with selected activity against ALK, ROS1 fusions, FLT3, IGF1R and mutant EGFR, potentially resulting in decreased tumor growth (PMID: 27780853). Alunbrig (brigatinib) is FDA approved for use in patients with ALK-positive non-small cell lung cancer who have progressed on or are intolerant to crizotinib (FDA.gov).

DrugClasses ALK Inhibitor 22 EGFR Inhibitor (Pan) 45 FLT3 Inhibitor 52 IGF-1R Inhibitor 17 ROS1 Inhibitor 14

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Brigatinib Bevacizumab Brigatinib 0 1
Binimetinib + Brigatinib Binimetinib Brigatinib 0 1
Brigatinib Brigatinib 115 12
Brigatinib + Carboplatin Brigatinib Carboplatin 0 1
Brigatinib + Cisplatin Brigatinib Cisplatin 0 1


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