Drug Detail


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Drug Name Brigatinib
Trade Name Alunbrig
Synonyms AP26113
Drug Descriptions

Alunbrig (brigatinib) is a multi-kinase inhibitor with selected activity against ALK, ROS1 fusions, FLT3, IGF1R and mutant EGFR, potentially resulting in decreased tumor growth (PMID: 27780853). Alunbrig (brigatinib) is FDA approved for use in patients with ALK-positive metastatic non-small cell lung cancer (FDA.gov).

DrugClasses ALK Inhibitor 32 EGFR Inhibitor (Pan) 61 FLT3 Inhibitor 68 IGF-1R Inhibitor 17 ROS1 Inhibitor 20
CAS Registry Number 1197953-54-0
NCIT ID C98831


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Therapy Name Drugs Efficacy Evidence Clinical Trials
AXL1717 + Brigatinib AXL1717 Brigatinib 0 0
Bevacizumab + Brigatinib Bevacizumab Brigatinib 0 1
Bevacizumab + Brigatinib + Osimertinib Bevacizumab Brigatinib Osimertinib 0 0
Binimetinib + Brigatinib Binimetinib Brigatinib 0 1
Brigatinib Brigatinib 174 19
Brigatinib + Carboplatin Brigatinib Carboplatin 0 1
Brigatinib + Carboplatin + Pemetrexed Disodium Brigatinib Carboplatin Pemetrexed Disodium 0 1
Brigatinib + Cetuximab Brigatinib Cetuximab 0 0
Brigatinib + Cetuximab + Icotinib Brigatinib Cetuximab Icotinib 0 0
Brigatinib + Cisplatin Brigatinib Cisplatin 0 1
Brigatinib + Dasatinib Brigatinib Dasatinib 0 0
Brigatinib + Entrectinib Brigatinib Entrectinib 0 0
Brigatinib + Necitumumab Brigatinib Necitumumab 0 0
Brigatinib + Osimertinib Brigatinib Osimertinib 0 0
Brigatinib + Panitumumab Brigatinib Panitumumab 0 0

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