Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Brigatinib
Trade Name Alunbrig
Synonyms AP26113
Drug Descriptions

Alunbrig (brigatinib) is a multi-kinase inhibitor with selected activity against ALK, ROS1 fusions, FLT3, IGF1R and mutant EGFR, potentially resulting in decreased tumor growth (PMID: 27780853). Alunbrig (brigatinib) is FDA approved for use in patients with ALK-positive metastatic non-small cell lung cancer (FDA.gov).

DrugClasses ALK Inhibitor 32 EGFR Inhibitor (Pan) 61 FLT3 Inhibitor 68 IGF-1R Inhibitor 17 ROS1 Inhibitor 20
CAS Registry Number 1197953-54-0
NCIT ID C98831

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
AXL1717 + Brigatinib AXL1717 Brigatinib 0 0
Bevacizumab + Brigatinib Bevacizumab Brigatinib 0 1
Bevacizumab + Brigatinib + Osimertinib Bevacizumab Brigatinib Osimertinib 0 0
Binimetinib + Brigatinib Binimetinib Brigatinib 0 1
Brigatinib Brigatinib 174 19
Brigatinib + Carboplatin Brigatinib Carboplatin 0 1
Brigatinib + Carboplatin + Pemetrexed Disodium Brigatinib Carboplatin Pemetrexed Disodium 0 1
Brigatinib + Cetuximab Brigatinib Cetuximab 0 0
Brigatinib + Cetuximab + Icotinib Brigatinib Cetuximab Icotinib 0 0
Brigatinib + Cisplatin Brigatinib Cisplatin 0 1
Brigatinib + Dasatinib Brigatinib Dasatinib 0 0
Brigatinib + Entrectinib Brigatinib Entrectinib 0 0
Brigatinib + Necitumumab Brigatinib Necitumumab 0 0
Brigatinib + Osimertinib Brigatinib Osimertinib 0 0
Brigatinib + Panitumumab Brigatinib Panitumumab 0 0


Additional content available in CKB BOOST