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Drug Name Larotrectinib
Trade Name Vitrakvi
Synonyms LOXO-101|ARRY-470
Drug Descriptions

Vitrakvi (larotrectinib) binds to and prevents activation of TRK receptors (NTRK1, -2, -3), resulting in decreased growth and increased apoptosis in Trk-expressing tumor cells (PMID: 29532798). Vitrakvi (larotrectinib) is FDA approved for use in adult and pediatric patients with solid tumors that have progressed, are metastatic, or are not surgically resectable and have an NTRK fusion without acquired resistance mutations (FDA.gov).

DrugClasses Trk Receptor Inhibitor (Pan) 23

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Dabrafenib + Larotrectinib + Trametinib Dabrafenib Larotrectinib Trametinib 0 0
Fulvestrant + Larotrectinib Fulvestrant Larotrectinib 0 0
Larotrectinib Larotrectinib 8 7
Larotrectinib + Trametinib Larotrectinib Trametinib 0 0


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