Drug Detail


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Drug Name Larotrectinib
Trade Name Vitrakvi
Synonyms LOXO-101|ARRY-470|BAY2757556
Drug Descriptions

Vitrakvi (larotrectinib) binds to and prevents activation of TRK receptors (NTRK1, -2, -3), resulting in decreased growth and increased apoptosis in Trk-expressing tumor cells (PMID: 29532798). Vitrakvi (larotrectinib) is FDA approved for use in adult and pediatric patients with solid tumors that have progressed, are metastatic, or are not surgically resectable and have an NTRK fusion without acquired resistance mutations (FDA.gov).

DrugClasses Trk Receptor Inhibitor (Pan) 31
CAS Registry Number 1223403-58-4
NCIT ID C115977


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Cyclophosphamide + Cytarabine + Larotrectinib + Venetoclax Azacitidine Cyclophosphamide Cytarabine Larotrectinib Venetoclax 0 0
Carboplatin + Etoposide + Larotrectinib Carboplatin Etoposide Larotrectinib 0 0
Dabrafenib + Larotrectinib + Trametinib Dabrafenib Larotrectinib Trametinib 0 0
Fulvestrant + Larotrectinib Fulvestrant Larotrectinib 0 0
Larotrectinib Larotrectinib 0 10
Larotrectinib + Selpercatinib Larotrectinib Selpercatinib 0 0
Larotrectinib + Trametinib Larotrectinib Trametinib 0 0

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