Drug Detail


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Drug Name CGM097
Trade Name
Synonyms NVP-CGM097
Drug Descriptions

CGM097 binds to the p53 binding region of MDM2 and prevents MDM2-p53 interaction, resulting in activation of p53 signaling and decreased tumor growth (Cancer Res October 1, 2014 74:4638, PMID: 32651541).

DrugClasses MDM2 Inhibitor 22
CAS Registry Number 1313363-54-0
NCIT ID C104280


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Alpelisib + CGM097 + Navitoclax + Trametinib Alpelisib CGM097 Navitoclax Trametinib 0 0
Ceritinib + CGM097 CGM097 Ceritinib 3 0
CGM097 CGM097 0 1
CGM097 + Dabrafenib + Navitoclax + PF-04217903 CGM097 Dabrafenib Navitoclax PF-04217903 1 0
CGM097 + Encorafenib CGM097 Encorafenib 1 0
CGM097 + Navitoclax + Trametinib CGM097 Navitoclax Trametinib 0 0
CGM097 + Sotrastaurin CGM097 Sotrastaurin 0 0
CGM097 + Trametinib CGM097 Trametinib 0 0
CGM097 + Venetoclax CGM097 Venetoclax 0 0

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