Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Sotrastaurin
Trade Name
Synonyms AEB071
Drug Descriptions

Sotrastaurin (AEB071) is a pan-PKC inhibitor, which induces cell cycle arrest and apoptosis (PMID: 19491325, PMID: 31261030).

DrugClasses PKC Inhibitor (Pan) 11
CAS Registry Number 425637-18-9
NCIT ID C80630


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Alpelisib + Sotrastaurin Alpelisib Sotrastaurin 0 1
Binimetinib + Sotrastaurin Binimetinib Sotrastaurin 0 1
CGM097 + Sotrastaurin CGM097 Sotrastaurin 0 0
Everolimus + Sotrastaurin Everolimus Sotrastaurin 0 1
PD-0325901 + Sotrastaurin PD-0325901 Sotrastaurin 0 0
Sotrastaurin Sotrastaurin 0 2

Additional content available in CKB BOOST