Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name PF-07284892
Trade Name
Synonyms PF 07284892|PF07284892|ARRY-558|ARRY 558|ARRY558
Drug Descriptions

PF-07284892 is a small molecule inhibitor of SHP2 that may block MAPK signaling and lead to tumor growth inhibition (PMID: 37269335).

DrugClasses SHP2 Inhibitor 20
CAS Registry Number NA
NCIT ID C178469


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Binimetinib + Encorafenib + PF-07284892 Binimetinib Encorafenib PF-07284892 1 0
Binimetinib + PF-07284892 Binimetinib PF-07284892 0 1
Cetuximab + Encorafenib + PF-07284892 Cetuximab Encorafenib PF-07284892 1 1
Lorlatinib + PF-07284892 Lorlatinib PF-07284892 2 1
PF-07284892 PF-07284892 0 1

Additional content available in CKB BOOST