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| Drug Name | Talazoparib |
| Trade Name | Talzenna |
| Synonyms | BMN673 |
| Drug Descriptions |
Talzenna (talazoparib) is an inhibitor of PARP1 and PARP2, which prevents the DNA repair of single strand DNA breaks, thus causing the accumulation of DNA strand breaks, genomic instability and apoptosis, and leads to lethality in homologous recombination repair deficient cells (PMID: 28242752). Talzenna (talazoparib) is FDA approved for use in patients with ERBB2 (HER2)-negative breast cancer harboring deleterious or suspected deleterious germline BRCA mutations (FDA.gov). |
| DrugClasses | PARP Inhibitor (Pan) 28 |
| CAS Registry Number | 1207456-01-6 |
| NCIT ID | C95733 |
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