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Drug Name Talazoparib
Trade Name Talzenna
Synonyms BMN673
Drug Descriptions

Talzenna (talazoparib) is an inhibitor of PARP1 and PARP2, which prevents the DNA repair of single strand DNA breaks, thus causing the accumulation of DNA strand breaks, genomic instability and apoptosis, and leads to lethality in homologous recombination repair deficient cells (PMID: 28242752). Talzenna (talazoparib) is FDA approved for use in patients with ERBB2 (HER2)-negative breast cancer harboring deleterious or suspected deleterious germline BRCA mutations (FDA.gov).

DrugClasses PARP Inhibitor (Pan) 19

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AGI-5198 + Talazoparib AGI-5198 Talazoparib 2 0
AsiDNA + Talazoparib AsiDNA Talazoparib 1 0
ASTX727 + Talazoparib ASTX727 Talazoparib 0 1
Avelumab + Binimetinib + Talazoparib Avelumab Binimetinib Talazoparib 0 1
Avelumab + Carboplatin + Paclitaxel + Talazoparib Avelumab Carboplatin Paclitaxel Talazoparib 0 1
Avelumab + NKTR-214 + Talazoparib Avelumab NKTR-214 Talazoparib 0 1
Avelumab + Talazoparib Avelumab Talazoparib 0 6
Axitinib + Talazoparib Axitinib Talazoparib 0 1
AZD6482 + Talazoparib AZD6482 Talazoparib 0 0
Carboplatin + Paclitaxel + Talazoparib Carboplatin Paclitaxel Talazoparib 0 3
CB-839 + Talazoparib CB-839 Talazoparib 0 1
Cisplatin + Talazoparib Cisplatin Talazoparib 1 0
CYT01B + Talazoparib CYT01B Talazoparib 1 0
Cytarabine + Talazoparib Cytarabine Talazoparib 0 0
Daunorubicin + Talazoparib Daunorubicin Talazoparib 2 0
Decitabine + Talazoparib Decitabine Talazoparib 0 1
Everolimus + Talazoparib Everolimus Talazoparib 0 0
Gedatolisib + Talazoparib Gedatolisib Talazoparib 0 1
Gemtuzumab ozogamicin + Talazoparib Gemtuzumab ozogamicin Talazoparib 0 1
Hydroxyurea + Talazoparib Hydroxyurea Talazoparib 0 0
Infigratinib + Talazoparib Infigratinib Talazoparib 0 0
Irinotecan + Talazoparib Irinotecan Talazoparib 0 2
KU-0063794 + Talazoparib KU-0063794 Talazoparib 0 0
Nivolumab + Talazoparib Nivolumab Talazoparib 0 1
Onalespib + Talazoparib Onalespib Talazoparib 0 1
Sacituzumab govitecan-hziy + Talazoparib Sacituzumab govitecan-hziy Talazoparib 0 1
SN-38 + Talazoparib SN-38 Talazoparib 1 0
Talazoparib Talazoparib 15 25
Talazoparib + Temozolomide Talazoparib Temozolomide 1 4
Talazoparib + VE-821 Talazoparib VE-821 0 0
Talazoparib + ZEN003694 Talazoparib ZEN003694 0 1
Talazoparib + ZN-c3 Talazoparib ZN-c3 0 1


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