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Drug Name Talazoparib
Trade Name Talzenna
Synonyms BMN673
Drug Descriptions

Talzenna (talazoparib) is an inhibitor of PARP1 and PARP2, which prevents the DNA repair of single strand DNA breaks, thus causing the accumulation of DNA strand breaks, genomic instability and apoptosis, and leads to lethality in homologous recombination repair deficient cells (PMID: 28242752). Talzenna (talazoparib) is FDA approved for use in patients with ERBB2 (HER2)-negative breast cancer harboring deleterious or suspected deleterious germline BRCA mutations (FDA.gov).

DrugClasses PARP Inhibitor (Pan) 23
CAS Registry Number 1207456-01-6
NCIT ID C95733

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Bicalutamide + Leuprolide + Prednisone + Talazoparib Abiraterone Bicalutamide Leuprolide Prednisone Talazoparib 0 1
Abiraterone + Degarelix + Prednisone + Talazoparib Abiraterone Degarelix Prednisone Talazoparib 0 1
Abiraterone + Goserelin + Prednisone + Talazoparib Abiraterone Goserelin Prednisone Talazoparib 0 1
AGI-5198 + Talazoparib AGI-5198 Talazoparib 2 0
ART4215 + Talazoparib ART4215 Talazoparib 0 1
AsiDNA + Talazoparib AsiDNA Talazoparib 0 0
Atezolizumab + Capecitabine + Talazoparib Atezolizumab Capecitabine Talazoparib 0 1
Atezolizumab + Talazoparib Atezolizumab Talazoparib 0 3
Avelumab + Binimetinib + Talazoparib Avelumab Binimetinib Talazoparib 0 1
Avelumab + Carboplatin + Paclitaxel + Talazoparib Avelumab Carboplatin Paclitaxel Talazoparib 0 1
Avelumab + NKTR-214 + Talazoparib Avelumab NKTR-214 Talazoparib 0 1
Avelumab + Talazoparib Avelumab Talazoparib 0 7
Axitinib + Talazoparib Axitinib Talazoparib 0 2
AZD6482 + Talazoparib AZD6482 Talazoparib 1 0
Belinostat + Talazoparib Belinostat Talazoparib 0 1
Berzosertib + Talazoparib Berzosertib Talazoparib 0 0
Capecitabine + Talazoparib Capecitabine Talazoparib 0 1
Carboplatin + Paclitaxel + Talazoparib Carboplatin Paclitaxel Talazoparib 0 3
CHIR99021 + Talazoparib CHIR99021 Talazoparib 0 0
Cisplatin + Talazoparib Cisplatin Talazoparib 1 0
Crizotinib + Talazoparib Crizotinib Talazoparib 0 1
CYT01B + Talazoparib CYT01B Talazoparib 0 0
Cytarabine + Talazoparib Cytarabine Talazoparib 0 0
Daunorubicin + Talazoparib Daunorubicin Talazoparib 2 0
Decitabine + Talazoparib Decitabine Talazoparib 0 1
Decitabine and Cedazuridine + Talazoparib Decitabine and Cedazuridine Talazoparib 0 1
Enzalutamide + Talazoparib Enzalutamide Talazoparib 0 2
Everolimus + Talazoparib Everolimus Talazoparib 0 0
Gedatolisib + Talazoparib Gedatolisib Talazoparib 0 1
Gemtuzumab ozogamicin + Talazoparib Gemtuzumab ozogamicin Talazoparib 0 1
Hydroxyurea + Talazoparib Hydroxyurea Talazoparib 0 0
Infigratinib + Talazoparib Infigratinib Talazoparib 0 0
Irinotecan + Talazoparib Irinotecan Talazoparib 0 3
KU-0063794 + Talazoparib KU-0063794 Talazoparib 0 0
LY2090314 + Talazoparib LY2090314 Talazoparib 0 0
Nivolumab + Talazoparib Nivolumab Talazoparib 0 1
Onalespib + Talazoparib Onalespib Talazoparib 0 1
Palbociclib + Talazoparib Palbociclib Talazoparib 0 1
RP-3500 + Talazoparib RP-3500 Talazoparib 0 1
Sacituzumab govitecan-hziy + Talazoparib Sacituzumab govitecan-hziy Talazoparib 0 1
SN-38 + Talazoparib SN-38 Talazoparib 0 0
Talazoparib Talazoparib 16 30
Talazoparib + Tazemetostat Talazoparib Tazemetostat 0 1
Talazoparib + Telaglenastat Talazoparib Telaglenastat 0 2
Talazoparib + Temozolomide Talazoparib Temozolomide 0 4
Talazoparib + Trifluridine-tipiracil hydrochloride Talazoparib Trifluridine-tipiracil hydrochloride 0 1
Talazoparib + unspecified PD-L1 antibody Talazoparib unspecified PD-L1 antibody 0 0
Talazoparib + VE-821 Talazoparib VE-821 0 0
Talazoparib + VX-803 Talazoparib VX-803 0 0
Talazoparib + ZEN-3694 Talazoparib ZEN-3694 0 2
Talazoparib + ZN-c3 Talazoparib ZN-c3 0 1


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