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|Therapy Name||Enzalutamide + Talazoparib|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Enzalutamide||Xtandi||MDV3100|ASP9785||Hormone - Anti-androgens 38||Xtandi (enzalutamide) is a second-generation small molecule androgen receptor (AR) inhibitor that inhibits AR signaling, thereby resulting in decreased tumor growth (PMID: 24009414, PMID: 25945058). Xtandi (enzalutamide) is FDA approved for use in patients with castration-resistant prostate cancer and metastatic hormone-sensitive prostate cancer (FDA.gov).|
|Talazoparib||Talzenna||BMN673||PARP Inhibitor (Pan) 25||Talzenna (talazoparib) is an inhibitor of PARP1 and PARP2, which prevents the DNA repair of single strand DNA breaks, thus causing the accumulation of DNA strand breaks, genomic instability and apoptosis, and leads to lethality in homologous recombination repair deficient cells (PMID: 28242752). Talzenna (talazoparib) is FDA approved for use in patients with ERBB2 (HER2)-negative breast cancer harboring deleterious or suspected deleterious germline BRCA mutations (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04821622||Phase III||Enzalutamide Enzalutamide + Talazoparib||Study of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPC||Recruiting||USA | ITA | FRA | ESP | DEU | CAN | BEL||19|
|NCT04332744||Phase II||Enzalutamide + Talazoparib Enzalutamide||Enzalutamide Plus Talazoparib for the Treatment of Hormone Sensitive Prostate Cancer (ZZ-First) (ZZ-First)||Recruiting||ESP||0|