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Drug Name Pacritinib
Trade Name Vonjo
Synonyms SB1518|SB-1518|SB 1518
Drug Descriptions

Vonjo (pacritinib) is an inhibitor of JAK2 and FLT3, with activity against JAK2 V617F and FLT3 ITD, which potentially increases tumor cell apoptosis, induces cell cycle arrest, and decreases tumor growth (PMID: 22829080, PMID: 21691275). Vonjo (pacritinib) is FDA approved for use in patients with primary or secondary myelofibrosis (FDA.gov).

DrugClasses FLT3 Inhibitor 66 JAK2 Inhibitor - ATP competitive 15
CAS Registry Number 937272-79-2
NCIT ID C78837


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Pacritinib Azacitidine Pacritinib 0 1
Cytarabine + Daunorubicin + Pacritinib Cytarabine Daunorubicin Pacritinib 1 1
Cytarabine + Pacritinib Cytarabine Pacritinib 0 1
Decitabine + Pacritinib Decitabine Pacritinib 1 3
Erlotinib + Pacritinib Erlotinib Pacritinib 0 1
Ibrutinib + Pacritinib Ibrutinib Pacritinib 0 1
Pacritinib Pacritinib 18 9
Pacritinib + Talazoparib Pacritinib Talazoparib 0 1

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