Drug Detail


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Drug Name Pacritinib
Trade Name
Synonyms SB1518|SB-1518|SB 1518
Drug Descriptions

Pacritinib (SB1518) is an inhibitor of JAK2 and FLT3, with activity against JAK2 V617F and FLT3 ITD, which potentially increases tumor cell apoptosis, induces cell cycle arrest, and decreases tumor growth (PMID: 22829080, PMID: 21691275).

DrugClasses FLT3 Inhibitor 55 JAK2 Inhibitor - ATP competitive 14
CAS Registry Number 937272-79-2
NCIT ID C78837


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cytarabine + Daunorubicin + Pacritinib Cytarabine Daunorubicin Pacritinib 0 1
Cytarabine + Pacritinib Cytarabine Pacritinib 0 1
Decitabine + Pacritinib Decitabine Pacritinib 0 3
Erlotinib + Pacritinib Erlotinib Pacritinib 0 1
Ibrutinib + Pacritinib Ibrutinib Pacritinib 0 1
Pacritinib Pacritinib 3 6

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