Drug Detail

Drug Name Pacritinib
Trade Name
Synonyms SB1518
Drug Descriptions

Pacritinib (SB1518) is an inhibitor of JAK2 and FLT3, with activity against JAK2 V617F and FLT3 ITD, which potentially increases tumor cell apoptosis, induces cell cycle arrest, and decreases tumor growth (PMID: 22829080, PMID: 21691275).

DrugClasses FLT3 Inhibitor 48 JAK2 Inhibitor - ATP competitive 14

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Therapy Name Therapy Description
Erlotinib + Pacritinib
Pacritinib + Cytarabine
Pacritinib Pacritinib (SB1518) is an inhibitor of JAK2 and FLT3, with activity against JAK2 V617F and FLT3 ITD, which potentially increases tumor cell apoptosis, induces cell cycle arrest, and decreases tumor growth (PMID: 22829080, PMID: 21691275).
Cytarabine + Daunorubicin + Pacritinib
Pacritinib + Decitabine
Ibrutinib + Pacritinib