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Drug Name Telaglenastat
Trade Name
Synonyms CB-839
Drug Descriptions

Telaglenastat (CB-839) binds to and inhibits glutaminase, preventing the conversion of glutamine to glutamate, which results in a decrease in cell proliferation (PMID: 31980651).

DrugClasses Glutaminase Inhibitor 3
CAS Registry Number 1439399-58-2
NCIT ID C114381


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Therapy Name Drugs Efficacy Evidence Clinical Trials
ARQ761 + Telaglenastat ARQ761 Telaglenastat 0 0
Azacitidine + Telaglenastat Azacitidine Telaglenastat 0 1
Cabozantinib + Telaglenastat Cabozantinib Telaglenastat 0 2
Capecitabine + Telaglenastat Capecitabine Telaglenastat 0 1
Carboplatin + Dexamethasone + Pembrolizumab + Pemetrexed Disodium + Telaglenastat Carboplatin Dexamethasone Pembrolizumab Pemetrexed Disodium Telaglenastat 0 1
Docetaxel + Telaglenastat Docetaxel Telaglenastat 0 1
Erlotinib + Telaglenastat Erlotinib Telaglenastat 0 1
Everolimus + Telaglenastat Everolimus Telaglenastat 0 2
Irinotecan + Panitumumab + Telaglenastat Irinotecan Panitumumab Telaglenastat 0 1
Niraparib + Telaglenastat Niraparib Telaglenastat 0 1
Nivolumab + Telaglenastat Nivolumab Telaglenastat 0 1
Olaparib + Telaglenastat Olaparib Telaglenastat 1 0
Osimertinib + Telaglenastat Osimertinib Telaglenastat 0 1
Paclitaxel + Telaglenastat Paclitaxel Telaglenastat 0 1
Palbociclib + Telaglenastat Palbociclib Telaglenastat 0 1
Radiotherapy + Telaglenastat Radiotherapy Telaglenastat 0 0
Radiotherapy + Telaglenastat + Temozolomide Radiotherapy Telaglenastat Temozolomide 0 1
Sapanisertib + Telaglenastat Sapanisertib Telaglenastat 0 1
Talazoparib + Telaglenastat Talazoparib Telaglenastat 0 2
Telaglenastat Telaglenastat 1 3

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