Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Telaglenastat
Trade Name
Synonyms CB-839
Drug Descriptions

Telaglenastat (CB-839) binds to and inhibits glutaminase, preventing the conversion of glutamine to glutamate, which results in a decrease in cell proliferation (PMID: 31980651).

DrugClasses Glutaminase Inhibitor 3
CAS Registry Number 1439399-58-2
NCIT ID C114381


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
ARQ761 + Telaglenastat ARQ761 Telaglenastat 0 0
Azacitidine + Telaglenastat Azacitidine Telaglenastat 0 1
Cabozantinib + Telaglenastat Cabozantinib Telaglenastat 0 2
Capecitabine + Telaglenastat Capecitabine Telaglenastat 0 1
Carboplatin + Dexamethasone + Pembrolizumab + Pemetrexed Disodium + Telaglenastat Carboplatin Dexamethasone Pembrolizumab Pemetrexed Disodium Telaglenastat 0 1
Cisplatin + Telaglenastat Cisplatin Telaglenastat 0 1
Docetaxel + Telaglenastat Docetaxel Telaglenastat 0 1
Erlotinib + Telaglenastat Erlotinib Telaglenastat 0 1
Everolimus + Telaglenastat Everolimus Telaglenastat 0 2
Irinotecan + Panitumumab + Telaglenastat Irinotecan Panitumumab Telaglenastat 0 1
Niraparib + Telaglenastat Niraparib Telaglenastat 0 1
Nivolumab + Telaglenastat Nivolumab Telaglenastat 0 1
Olaparib + Telaglenastat Olaparib Telaglenastat 1 0
Osimertinib + Telaglenastat Osimertinib Telaglenastat 0 1
Paclitaxel + Telaglenastat Paclitaxel Telaglenastat 0 1
Palbociclib + Telaglenastat Palbociclib Telaglenastat 0 1
Radiotherapy + Telaglenastat Radiotherapy Telaglenastat 0 0
Radiotherapy + Telaglenastat + Temozolomide Radiotherapy Telaglenastat Temozolomide 0 1
Sapanisertib + Telaglenastat Sapanisertib Telaglenastat 0 1
Talazoparib + Telaglenastat Talazoparib Telaglenastat 0 2
Telaglenastat Telaglenastat 1 3

Additional content available in CKB BOOST