Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name CB-839
Trade Name
Synonyms
Drug Descriptions

CB-839 binds to and inhibits glutaminase, preventing the conversion of glutamine to glutamate, which results in a decrease in cell proliferation (NCI Drug Dictionary).

DrugClasses

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
ARQ761 + CB-839 ARQ761 CB-839 0 0
Azacitidine + CB-839 Azacitidine CB-839 0 1
Cabozantinib + CB-839 CB-839 Cabozantinib 0 2
Capecitabine + CB-839 CB-839 Capecitabine 0 1
CB-839 CB-839 1 3
CB-839 + Docetaxel CB-839 Docetaxel 0 1
CB-839 + Erlotinib CB-839 Erlotinib 0 1
CB-839 + Everolimus CB-839 Everolimus 1 2
CB-839 + Irinotecan + Panitumumab CB-839 Irinotecan Panitumumab 0 1
CB-839 + Niraparib CB-839 Niraparib 0 1
CB-839 + Nivolumab CB-839 Nivolumab 0 1
CB-839 + Olaparib CB-839 Olaparib 1 0
CB-839 + Osimertinib CB-839 Osimertinib 0 1
CB-839 + Paclitaxel CB-839 Paclitaxel 0 1
CB-839 + Palbociclib CB-839 Palbociclib 0 1
CB-839 + Radiotherapy + Temozolomide CB-839 Radiotherapy Temozolomide 0 1
CB-839 + Talazoparib CB-839 Talazoparib 0 1


Additional content available in CKB BOOST