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Drug Name Dostarlimab-gxly
Trade Name Jemperli
Synonyms TSR-042
Drug Descriptions

Jemperli (dostarlimab-gxly) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 34313545). Jemperli (dostarlimab-gxly) is FDA approved for use in patients with recurrent or advanced endometrial cancer or solid tumors harboring mismatch repair deficient (dMMR), as determined by an FDA-approved test, who have progressed on prior treatments (FDA.gov).

DrugClasses Immune Checkpoint Inhibitor 135 PD-L1/PD-1 antibody 79
CAS Registry Number 2022215-59-2
NCIT ID C126799

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Dostarlimab-gxly + Niraparib Bevacizumab Dostarlimab-gxly Niraparib 0 2
Bevacizumab + Dostarlimab-gxly + Paclitaxel Bevacizumab Dostarlimab-gxly Paclitaxel 0 1
Capecitabine + Dostarlimab-gxly Capecitabine Dostarlimab-gxly 0 1
Carboplatin + Dostarlimab-gxly + Paclitaxel Carboplatin Dostarlimab-gxly Paclitaxel 0 2
Carboplatin + Dostarlimab-gxly + Pemetrexed Disodium Carboplatin Dostarlimab-gxly Pemetrexed Disodium 0 1
Cisplatin + Dostarlimab-gxly + Pemetrexed Disodium Cisplatin Dostarlimab-gxly Pemetrexed Disodium 0 1
Docetaxel + Dostarlimab-gxly Docetaxel Dostarlimab-gxly 0 1
Docetaxel + Dostarlimab-gxly + TSR-022 Docetaxel Dostarlimab-gxly TSR-022 0 1
Dostarlimab-gxly Dostarlimab-gxly 24 6
Dostarlimab-gxly + Fluorouracil Dostarlimab-gxly Fluorouracil 0 1
Dostarlimab-gxly + GSK6097608 Dostarlimab-gxly GSK6097608 0 1
Dostarlimab-gxly + Niraparib Dostarlimab-gxly Niraparib 0 17
Dostarlimab-gxly + TSR-022 Dostarlimab-gxly TSR-022 0 2
Dostarlimab-gxly + TSR-033 Dostarlimab-gxly TSR-033 0 0


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