Drug Detail


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Drug Name Dostarlimab-gxly
Trade Name Jemperli
Synonyms TSR-042
Drug Descriptions

Jemperli (dostarlimab-gxly) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 34313545). Jemperli (dostarlimab-gxly) is FDA approved for use in patients with recurrent or advanced endometrial cancer or solid tumors harboring mismatch repair deficient (dMMR), as determined by an FDA-approved test, who have progressed on prior treatments, and in combination with Paraplatin (carboplatin) and Taxol (paclitaxel), followed by Jemperli (dostarlimab-gxly) monotherapy, in patients with primary advanced or recurrent endometrial cancer that is mismatch repair deficient (dMMR), as determined by an FDA-approved test, or microsatellite instability-high (MSI-H) (FDA.gov).

DrugClasses Immune Checkpoint Inhibitor 147 PD-L1/PD-1 antibody 117
CAS Registry Number 2022215-59-2
NCIT ID C126799


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Therapy Name Drugs Efficacy Evidence Clinical Trials
belantamab mafodotin-blmf + Dostarlimab-gxly Dostarlimab-gxly belantamab mafodotin-blmf 0 1
Bevacizumab + Dostarlimab-gxly + Niraparib Bevacizumab Dostarlimab-gxly Niraparib 0 2
Bevacizumab + Dostarlimab-gxly + Paclitaxel Bevacizumab Dostarlimab-gxly Paclitaxel 0 1
Cabozantinib + Dostarlimab-gxly Cabozantinib Dostarlimab-gxly 0 1
Capecitabine + Dostarlimab-gxly Capecitabine Dostarlimab-gxly 0 1
Carboplatin + Dostarlimab-gxly Carboplatin Dostarlimab-gxly 0 0
Carboplatin + Dostarlimab-gxly + HM30181A + Paclitaxel Carboplatin Dostarlimab-gxly HM30181A Paclitaxel 0 1
Carboplatin + Dostarlimab-gxly + HM30181A + Paclitaxel + Trastuzumab Carboplatin Dostarlimab-gxly HM30181A Paclitaxel Trastuzumab 0 1
Carboplatin + Dostarlimab-gxly + Paclitaxel Carboplatin Dostarlimab-gxly Paclitaxel 4 3
Carboplatin + Dostarlimab-gxly + Pemetrexed Disodium Carboplatin Dostarlimab-gxly Pemetrexed Disodium 0 1
Cisplatin + Cobolimab + Dostarlimab-gxly + Pemetrexed Disodium Cisplatin Cobolimab Dostarlimab-gxly Pemetrexed Disodium 0 1
Cisplatin + Dostarlimab-gxly + Niraparib Cisplatin Dostarlimab-gxly Niraparib 0 1
Cisplatin + Dostarlimab-gxly + Paclitaxel Cisplatin Dostarlimab-gxly Paclitaxel 0 1
Cisplatin + Dostarlimab-gxly + Pemetrexed Disodium Cisplatin Dostarlimab-gxly Pemetrexed Disodium 0 1
Cobolimab + Docetaxel + Dostarlimab-gxly Cobolimab Docetaxel Dostarlimab-gxly 0 2
Cobolimab + Dostarlimab-gxly Cobolimab Dostarlimab-gxly 0 4
Cobolimab + Dostarlimab-gxly + TSR-033 Cobolimab Dostarlimab-gxly TSR-033 0 1
Docetaxel + Dostarlimab-gxly Docetaxel Dostarlimab-gxly 0 1
Dostarlimab-gxly Dostarlimab-gxly 94 14
Dostarlimab-gxly + EOS-448 Dostarlimab-gxly EOS-448 0 2
Dostarlimab-gxly + EOS-448 + GSK4381562 Dostarlimab-gxly EOS-448 GSK4381562 0 1
Dostarlimab-gxly + EOS-448 + GSK6097608 Dostarlimab-gxly EOS-448 GSK6097608 0 1
Dostarlimab-gxly + Fluorouracil Dostarlimab-gxly Fluorouracil 0 1
Dostarlimab-gxly + GSK4381562 Dostarlimab-gxly GSK4381562 0 1
Dostarlimab-gxly + GSK6097608 Dostarlimab-gxly GSK6097608 0 2
Dostarlimab-gxly + LB-100 Dostarlimab-gxly LB-100 0 1
Dostarlimab-gxly + Niraparib Dostarlimab-gxly Niraparib 0 25
Dostarlimab-gxly + TSR-033 Dostarlimab-gxly TSR-033 0 0

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