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Drug Name LB-100
Trade Name
Synonyms LB100|LB 100
Drug Descriptions

LB-100 is a small molecule that inhibits PP2A activity, resulting in increased sensitivity of tumor cells to DNA damaging agents, including chemotherapy and radiotherapy (PMID: 25376608, PMID: 31935881, PMID: 30679389, PMID: 32342332).

DrugClasses PP2A Inhibitor 2
CAS Registry Number 1632032-53-1
NCIT ID C106430


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Carboplatin + Etoposide + LB-100 Atezolizumab Carboplatin Etoposide LB-100 0 1
Atezolizumab + LB-100 Atezolizumab LB-100 0 1
Ceralasertib + LB-100 Ceralasertib LB-100 0 0
Cisplatin + LB-100 Cisplatin LB-100 2 0
Docetaxel + LB-100 Docetaxel LB-100 0 1
Dostarlimab-gxly + LB-100 Dostarlimab-gxly LB-100 0 1
Doxorubicin + LB-100 Doxorubicin LB-100 0 1
LB-100 LB-100 0 2
LB-100 + LY2603618 LB-100 LY2603618 0 0

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