Drug Detail


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Drug Name EOS-448
Trade Name
Synonyms EOS 448|EOS448|EOS884448|GSK4428859A|Belrestotug
Drug Descriptions

EOS-448 is a monoclonal antibody that binds to T cell Immunoreceptor with Ig and ITIM domains (TIGIT) and inhibits ligand interaction, potentially leading to increased antitumor immune response (Cancer Res 2020;80(16 Suppl):Abstract nr 3161; Cancer Res 2021;81(13_Suppl):Abstract nr CT118).

DrugClasses TIGIT Antibody 19
CAS Registry Number 2574438-65-4
NCIT ID C176746


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Dexamethasone + EOS-448 + Iberdomide Dexamethasone EOS-448 Iberdomide 0 1
Dostarlimab-gxly + EOS-448 Dostarlimab-gxly EOS-448 0 2
Dostarlimab-gxly + EOS-448 + GSK4381562 Dostarlimab-gxly EOS-448 GSK4381562 0 1
Dostarlimab-gxly + EOS-448 + GSK6097608 Dostarlimab-gxly EOS-448 GSK6097608 0 1
EOS-448 EOS-448 0 1
EOS-448 + EOS100850 EOS-448 EOS100850 0 1
EOS-448 + Iberdomide EOS-448 Iberdomide 0 1
EOS-448 + Pembrolizumab EOS-448 Pembrolizumab 0 1

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