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Drug Name Bemcentinib
Trade Name
Synonyms BGB-324|BGB324|R428|R-428
Drug Descriptions

Bemcentinib (BGB-324) is a small molecule inhibitor of Axl, which inhibits tumor growth and may overcome EMT-mediated acquired drug resistance (PMID: 20145120, PMID: 31134766).

DrugClasses AXL Inhibitor 27

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bemcentinib Bemcentinib 1 2
Bemcentinib + Ceritinib Bemcentinib Ceritinib 0 0
Bemcentinib + Cetuximab Bemcentinib Cetuximab 0 0
Bemcentinib + Cisplatin + Gemcitabine + Nab-paclitaxel Bemcentinib Cisplatin Gemcitabine Nab-paclitaxel 0 1
Bemcentinib + Crizotinib Bemcentinib Crizotinib 0 0
Bemcentinib + Docetaxel Bemcentinib Docetaxel 0 1
Bemcentinib + Erlotinib Bemcentinib Erlotinib 0 1
Bemcentinib + Imatinib Bemcentinib Imatinib 0 0
Bemcentinib + Metformin Bemcentinib Metformin 0 0
Bemcentinib + Olaparib Bemcentinib Olaparib 0 0
Bemcentinib + Pembrolizumab Bemcentinib Pembrolizumab 0 2


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