Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name AC480
Trade Name
Synonyms BMS-599626|AC-480
Drug Descriptions

AC480 (BMS-599626) is an inhibitor of EGFR and ERBB2 (HER2), which may prevent downstream signaling and inhibit the proliferation of tumor cells that overexpress these receptors (PMID: 17062696, PMID: 21576284).

DrugClasses EGFR Inhibitor (Pan) 54 HER2 Inhibitor 33
CAS Registry Number 714971-09-2
NCIT ID C48380


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
AC480 AC480 0 0
AC480 + Doxorubicin AC480 Doxorubicin 0 0
AC480 + Mitoxantrone AC480 Mitoxantrone 0 0
AC480 + Topotecan AC480 Topotecan 0 0
AC480 + Vincristine Sulfate AC480 Vincristine Sulfate 0 0

Additional content available in CKB BOOST