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Drug Name Mitoxantrone
Trade Name Novantrone
Synonyms CL 232315
Drug Descriptions

Novantrone (Mitoxantrone) binds to and inhibits topoisomerase II, leading to DNA double strand breaks and decreased DNA repair (NCI Drug Dictionary).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bortezomib + Cytarabine + Etoposide + Midostaurin + Mitoxantrone Bortezomib Cytarabine Etoposide Midostaurin Mitoxantrone 1 0
Cladribine + Cytarabine + Filgrastim + Gemtuzumab ozogamicin + Mitoxantrone Cladribine Cytarabine Filgrastim Gemtuzumab ozogamicin Mitoxantrone 0 1
Cladribine + Cytarabine + Filgrastim + Mitoxantrone Cladribine Cytarabine Filgrastim Mitoxantrone 0 2
CPI-613 + Cytarabine + Mitoxantrone CPI-613 Cytarabine Mitoxantrone 1 1
Crenolanib + Cytarabine + Filgrastim + Fludarabine + Idarubicin + Mitoxantrone Crenolanib Cytarabine Filgrastim Fludarabine Idarubicin Mitoxantrone 0 1
Crenolanib + Cytarabine + Mitoxantrone Crenolanib Cytarabine Mitoxantrone 0 1
Custirsen + Mitoxantrone + Prednisone Custirsen Mitoxantrone Prednisone 0 0
Cytarabine + Daunorubicin + Etoposide + Mitoxantrone Cytarabine Daunorubicin Etoposide Mitoxantrone 0 0
Cytarabine + Dexamethasone + Idarubicin + Mitoxantrone Cytarabine Dexamethasone Idarubicin Mitoxantrone 0 1
Cytarabine + Etoposide + Mitoxantrone Cytarabine Etoposide Mitoxantrone 0 8
Cytarabine + Etoposide + Mitoxantrone + MSC2490484A Cytarabine Etoposide MSC2490484A Mitoxantrone 0 1
Cytarabine + Etoposide + Mitoxantrone + Prexasertib Cytarabine Etoposide Mitoxantrone Prexasertib 0 1
Cytarabine + Etoposide + Mitoxantrone + Sirolimus Cytarabine Etoposide Mitoxantrone Sirolimus 0 1
Cytarabine + Etoposide + Mitoxantrone + Uproleselan Cytarabine Etoposide Mitoxantrone Uproleselan 0 1
Cytarabine + Filgrastim + Fludarabine + Idarubicin + Mitoxantrone Cytarabine Filgrastim Fludarabine Idarubicin Mitoxantrone 0 1
Cytarabine + Mitoxantrone Cytarabine Mitoxantrone 0 5
Cytarabine + Mitoxantrone + Sorafenib Cytarabine Mitoxantrone Sorafenib 0 1
Dexamethasone + Methotrexate + Mitoxantrone + Pegaspargase + Vincristine sulfate liposome Dexamethasone Methotrexate Mitoxantrone Pegaspargase Vincristine sulfate liposome 0 1
Enasidenib + Etoposide + Mitoxantrone Enasidenib Etoposide Mitoxantrone 0 1
Etoposide + Gemtuzumab ozogamicin + Mitoxantrone Etoposide Gemtuzumab ozogamicin Mitoxantrone 0 1
Etoposide + Ivosidenib + Mitoxantrone Etoposide Ivosidenib Mitoxantrone 0 1
Mitoxantrone Mitoxantrone 0 10


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