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Drug Name MSC2490484A
Trade Name
Synonyms M3814|M-3814|Nedisertib|Peposertib
Drug Descriptions

Peposertib (MSC2490484A) is a DNA-dependent protein kinase (DNA-PK) inhibitor that blocks DNA damage repair, which may lead to antitumor activity by sensitizing cancer cells to radiation and agents that induce DNA double strand breaks (PMID: 32220971).

DrugClasses DNA_PK Inhibitor 6
CAS Registry Number 1637542-33-6
NCIT ID C120036


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Avelumab + MSC2490484A Avelumab MSC2490484A 0 2
Avelumab + MSC2490484A + Radium Ra 223 dichloride Avelumab MSC2490484A Radium Ra 223 dichloride 0 1
Capecitabine + MSC2490484A Capecitabine MSC2490484A 0 1
Cisplatin + Etoposide + MSC2490484A Cisplatin Etoposide MSC2490484A 0 1
Cytarabine + Etoposide + Mitoxantrone + MSC2490484A Cytarabine Etoposide MSC2490484A Mitoxantrone 0 1
lutetium Lu 177 dotatate + MSC2490484A MSC2490484A lutetium Lu 177 dotatate 0 1
MSC2490484A MSC2490484A 0 5
MSC2490484A + Pegylated liposomal-doxorubicin MSC2490484A Pegylated liposomal-doxorubicin 0 1
MSC2490484A + Radium Ra 223 dichloride MSC2490484A Radium Ra 223 dichloride 0 1
MSC2490484A + unspecified PD-L1 antibody MSC2490484A unspecified PD-L1 antibody 0 0

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