Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name MSC2490484A
Trade Name
Synonyms M3814|M-3814|Nedisertib|Peposertib
Drug Descriptions

Peposertib (MSC2490484A) is a DNA-dependent protein kinase (DNA-PK) inhibitor that blocks DNA damage repair, which may lead to antitumor activity by sensitizing cancer cells to radiation and agents that induce DNA double strand breaks (PMID: 32220971).

DrugClasses DNA_PK Inhibitor 6

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Avelumab + MSC2490484A Avelumab MSC2490484A 0 2
Capecitabine + MSC2490484A Capecitabine MSC2490484A 0 1
Cisplatin + Etoposide + MSC2490484A Cisplatin Etoposide MSC2490484A 0 1
Cytarabine + Etoposide + Mitoxantrone + MSC2490484A Cytarabine Etoposide MSC2490484A Mitoxantrone 0 1
MSC2490484A MSC2490484A 1 2
MSC2490484A + Pegylated liposomal-doxorubicin MSC2490484A Pegylated liposomal-doxorubicin 0 1
MSC2490484A + unspecified PD-L1 antibody MSC2490484A unspecified PD-L1 antibody 1 0


Additional content available in CKB BOOST