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Drug Name Peposertib
Trade Name
Synonyms M3814|M-3814|Nedisertib|MSC2490484A
Drug Descriptions

Peposertib (MSC2490484A) is a DNA-dependent protein kinase (DNA-PK) inhibitor that blocks DNA damage repair, which may lead to antitumor activity by sensitizing cancer cells to radiation and agents that induce DNA double strand breaks (PMID: 32220971).

DrugClasses DNA_PK Inhibitor 7
CAS Registry Number 1637542-33-6
NCIT ID C120036

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Avelumab + Peposertib Avelumab Peposertib 0 2
Avelumab + Peposertib + Radium Ra 223 dichloride Avelumab Peposertib Radium Ra 223 dichloride 0 1
Capecitabine + Peposertib Capecitabine Peposertib 0 1
Cisplatin + Etoposide + Peposertib Cisplatin Etoposide Peposertib 0 1
Cytarabine + Etoposide + Mitoxantrone + Peposertib Cytarabine Etoposide Mitoxantrone Peposertib 0 1
lutetium Lu 177 dotatate + Peposertib Peposertib lutetium Lu 177 dotatate 0 1
Pegylated liposomal-doxorubicin + Peposertib Pegylated liposomal-doxorubicin Peposertib 0 1
Peposertib Peposertib 0 5
Peposertib + Radium Ra 223 dichloride Peposertib Radium Ra 223 dichloride 0 1
Peposertib + unspecified PD-L1 antibody Peposertib unspecified PD-L1 antibody 0 0


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