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|Therapy Name||Capecitabine + MSC2490484A|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Capecitabine||Xeloda||R340||Chemotherapy - Antimetabolite 11||Xeloda (capecitabine) is an antimetabolite that when activated to 5-FU ultimately inhibits DNA synthesis and cell division (NCI Drug Dictionary).|
|MSC2490484A||M3814|M-3814|Nedisertib|Peposertib||DNA_PK Inhibitor 6||Peposertib (MSC2490484A) is a DNA-dependent protein kinase (DNA-PK) inhibitor that blocks DNA damage repair, which may lead to antitumor activity by sensitizing cancer cells to radiation and agents that induce DNA double strand breaks (PMID: 32220971).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT03770689||Phase Ib/II||Capecitabine Capecitabine + MSC2490484A||Phase Ib/II Study of M3814 in Combination With Capecitabine and Radiotherapy in Rectal Cancer||Recruiting|