Drug Detail


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Drug Name Ivosidenib
Trade Name Tibsovo
Synonyms AG-120
Drug Descriptions

Tibsovo (ivosidenib) inhibits mutant IDH1, leading to increased differentiation and decreased proliferation in IDH1 positive tumors (PMID: 27245312). Tibsovo (ivosidenib) is FDA approved for adult patients with relapsed or refractory IDH1-mutant (R132C/G/H/L/S) acute myeloid leukemia (AML) or myelodysplastic syndrome, patients 75 years or older with newly diagnosed IDH1-mutant AML, in combination with Vidaza (azacitidine) for patients with newly-diagnosed IDH1-mutant AML, and patients with advanced or metastatic IDH1-mutant cholangiocarcinoma (FDA.gov).

DrugClasses IDH1 Inhibitor 8
CAS Registry Number 1448347-49-6
NCIT ID C114383


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Enasidenib + Ivosidenib + Venetoclax Azacitidine Enasidenib Ivosidenib Venetoclax 0 0
Azacitidine + Ivosidenib Azacitidine Ivosidenib 10 3
Azacitidine + Ivosidenib + Venetoclax Azacitidine Ivosidenib Venetoclax 1 2
Cisplatin + Gemcitabine + Ivosidenib Cisplatin Gemcitabine Ivosidenib 0 1
CPX-351 + Ivosidenib CPX-351 Ivosidenib 0 1
Cytarabine + Daunorubicin + Ivosidenib Cytarabine Daunorubicin Ivosidenib 0 1
Cytarabine + Filgrastim + Fludarabine + Ivosidenib Cytarabine Filgrastim Fludarabine Ivosidenib 0 1
Cytarabine + Idarubicin + Ivosidenib Cytarabine Idarubicin Ivosidenib 0 1
Cytarabine + Ivosidenib Cytarabine Ivosidenib 0 1
Decitabine and Cedazuridine + Ivosidenib Decitabine and Cedazuridine Ivosidenib 0 1
Decitabine and Cedazuridine + Ivosidenib + Venetoclax Decitabine and Cedazuridine Ivosidenib Venetoclax 0 1
Enasidenib + Ivosidenib Enasidenib Ivosidenib 0 0
Etoposide + Ivosidenib + Mitoxantrone Etoposide Ivosidenib Mitoxantrone 0 1
Fedratinib + Ivosidenib Fedratinib Ivosidenib 0 1
Fluorouracil + Irinotecan + Ivosidenib + Leucovorin + Oxaliplatin Fluorouracil Irinotecan Ivosidenib Leucovorin Oxaliplatin 0 1
Gilteritinib + Ivosidenib Gilteritinib Ivosidenib 0 1
Glasdegib + Ivosidenib Glasdegib Ivosidenib 0 1
Ipilimumab + Ivosidenib + Nivolumab Ipilimumab Ivosidenib Nivolumab 0 1
Ivosidenib Ivosidenib 57 13
Ivosidenib + Nivolumab Ivosidenib Nivolumab 0 1
Ivosidenib + Ruxolitinib Ivosidenib Ruxolitinib 0 1
Ivosidenib + Venetoclax Ivosidenib Venetoclax 1 1

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