Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Ivosidenib
Trade Name Tibsovo
Synonyms AG-120
Drug Descriptions

Tibsovo (ivosidenib) inhibits mutant IDH1, leading to increased differentiation and decreased proliferation in IDH1 positive tumors (PMID: 27245312). Tibsovo (ivosidenib) is FDA approved for adult patients with relapsed or refractory IDH1-mutant (R132C/G/H/L/S) acute myeloid leukemia, patients 75 years or older with newly diagnosed IDH1-mutant acute myeloid leukemia, and patients with advanced or metastatic IDH1-mutant cholangiocarcinoma (FDA.gov).

DrugClasses IDH1 Inhibitor 8
CAS Registry Number 1448347-49-6
NCIT ID C114383

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Ivosidenib Azacitidine Ivosidenib 3 2
Azacitidine + Ivosidenib + Venetoclax Azacitidine Ivosidenib Venetoclax 1 1
Cisplatin + Gemcitabine + Ivosidenib Cisplatin Gemcitabine Ivosidenib 0 1
CPX-351 + Ivosidenib CPX-351 Ivosidenib 0 1
Cytarabine + Daunorubicin + Ivosidenib Cytarabine Daunorubicin Ivosidenib 0 1
Cytarabine + Filgrastim + Fludarabine + Ivosidenib Cytarabine Filgrastim Fludarabine Ivosidenib 0 1
Cytarabine + Idarubicin + Ivosidenib Cytarabine Idarubicin Ivosidenib 0 1
Cytarabine + Ivosidenib Cytarabine Ivosidenib 0 1
Decitabine and Cedazuridine + Ivosidenib Decitabine and Cedazuridine Ivosidenib 0 1
Decitabine and Cedazuridine + Ivosidenib + Venetoclax Decitabine and Cedazuridine Ivosidenib Venetoclax 0 1
Enasidenib + Ivosidenib Enasidenib Ivosidenib 0 0
Etoposide + Ivosidenib + Mitoxantrone Etoposide Ivosidenib Mitoxantrone 0 1
Fedratinib + Ivosidenib Fedratinib Ivosidenib 0 1
Glasdegib + Ivosidenib Glasdegib Ivosidenib 0 1
Ivosidenib Ivosidenib 28 11
Ivosidenib + Nivolumab Ivosidenib Nivolumab 0 1
Ivosidenib + Venetoclax Ivosidenib Venetoclax 1 1


Additional content available in CKB BOOST