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Drug Name Ivosidenib
Trade Name Tibsovo
Synonyms AG-120
Drug Descriptions

Tibsovo (ivosidenib) inhibits mutant IDH1, leading to increased differentiation and decreased proliferation in IDH1 positive tumors (PMID: 27245312). Tibsovo (ivosidenib) is FDA approved for adult patients with relapsed or refractory IDH1-mutant (R132C/G/H/L/S) acute myeloid leukemia, and in patients 75 years or older with newly diagnosed IDH1-mutant acute myeloid leukemia (FDA.gov).

DrugClasses IDH1 Inhibitor 8

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Ivosidenib Azacitidine Ivosidenib 1 2
Azacitidine + Ivosidenib + Venetoclax Azacitidine Ivosidenib Venetoclax 1 0
Cisplatin + Gemcitabine + Ivosidenib Cisplatin Gemcitabine Ivosidenib 0 1
CPX-351 + Ivosidenib CPX-351 Ivosidenib 0 1
Cytarabine + Daunorubicin + Ivosidenib Cytarabine Daunorubicin Ivosidenib 0 1
Cytarabine + Filgrastim + Fludarabine + Ivosidenib Cytarabine Filgrastim Fludarabine Ivosidenib 0 1
Cytarabine + Idarubicin + Ivosidenib Cytarabine Idarubicin Ivosidenib 0 1
Cytarabine + Ivosidenib Cytarabine Ivosidenib 0 1
Etoposide + Ivosidenib + Mitoxantrone Etoposide Ivosidenib Mitoxantrone 0 1
Ivosidenib Ivosidenib 24 10
Ivosidenib + Nivolumab Ivosidenib Nivolumab 0 1
Ivosidenib + Venetoclax Ivosidenib Venetoclax 1 1


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