Drug Detail


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Drug Name CPX-351
Trade Name Vyxeos
Synonyms Liposome-encapsulated Daunorubicin-Cytarabine
Drug Descriptions

Vyxeos (CPX-351) is a liposomal formulation of cytarabine and daunorubicin with anti-tumor activities (PMID: 25223583). Vyxeos (CPX-351) is FDA approved for use in patients with newly-diagnosed therapy-related acute myeloid leukemia (AML) or AML with myelodysplasia-related changes (FDA.gov).

CAS Registry Number NA
NCIT ID C67504


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Busulfan + CPX-351 + Fludarabine + Melphalan + Midostaurin Busulfan CPX-351 Fludarabine Melphalan Midostaurin 0 1
CPX-351 CPX-351 0 20
CPX-351 + Cytarabine + Filgrastim + Fludarabine CPX-351 Cytarabine Filgrastim Fludarabine 0 1
CPX-351 + Enasidenib CPX-351 Enasidenib 0 2
CPX-351 + Gemtuzumab ozogamicin CPX-351 Gemtuzumab ozogamicin 0 5
CPX-351 + Gilteritinib CPX-351 Gilteritinib 0 1
CPX-351 + Glasdegib CPX-351 Glasdegib 0 1
CPX-351 + Ivosidenib CPX-351 Ivosidenib 0 1
CPX-351 + Midostaurin CPX-351 Midostaurin 0 1
CPX-351 + Palbociclib CPX-351 Palbociclib 0 1
CPX-351 + Palbociclib + Tazemetostat CPX-351 Palbociclib Tazemetostat 0 1
CPX-351 + Quizartinib CPX-351 Quizartinib 0 2
CPX-351 + Ruxolitinib CPX-351 Ruxolitinib 0 1
CPX-351 + Venetoclax CPX-351 Venetoclax 0 5

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