Drug Detail


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Drug Name Glasdegib
Trade Name Daurismo
Synonyms PF-04449913
Drug Descriptions

Daurismo (glasdegib) inhibits Smoothened (SMO), resulting in decreased Hedgehog (Hh) pathway signalling, and potentially inhibiting Hh-mediated tumor growth (PMID: 24900436, PMID: 25388167). Daurismo (glasdegib) is FDA approved for use in combination with low-dose cytarabine in patients 75 years old or older with newly-diagnosed acute myeloid leukemia (FDA.gov).

DrugClasses SMO Inhibitor 16
CAS Registry Number 1095173-27-5
NCIT ID C84862


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Avelumab + Glasdegib Avelumab Glasdegib 0 1
Azacitidine + Glasdegib Azacitidine Glasdegib 1 3
Bosutinib + Glasdegib Bosutinib Glasdegib 0 1
CPX-351 + Glasdegib CPX-351 Glasdegib 0 1
Cytarabine + Daunorubicin + Glasdegib Cytarabine Daunorubicin Glasdegib 0 1
Cytarabine + Glasdegib Cytarabine Glasdegib 0 0
Decitabine + Glasdegib Decitabine Glasdegib 0 2
Decitabine + Glasdegib + Venetoclax Decitabine Glasdegib Venetoclax 0 1
Enasidenib + Glasdegib Enasidenib Glasdegib 0 1
Gemtuzumab ozogamicin + Glasdegib Gemtuzumab ozogamicin Glasdegib 0 3
Gilteritinib + Glasdegib Gilteritinib Glasdegib 0 1
Glasdegib Glasdegib 0 5
Glasdegib + Ivosidenib Glasdegib Ivosidenib 0 1
Glasdegib + Temozolomide Glasdegib Temozolomide 0 1

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