Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Busulfan
Trade Name Busulfex
Synonyms Busulphan
Drug Descriptions

Busulfex (busulfan) inhibits DNA replication and RNA transcription, likely through induction of DNA alkylation (PMID: 27481448). Busulfex (busulfan) in combination with cyclophosphamide is FDA approved as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for patients with chronic myelogenous leukemia (FDA.gov).

DrugClasses

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
anti-thymocyte globulin + Busulfan + Clofarabine Busulfan Clofarabine anti-thymocyte globulin 0 3
anti-thymocyte globulin + Busulfan + Clofarabine + Fludarabine + haNK cells Busulfan Clofarabine Fludarabine anti-thymocyte globulin haNK cells 0 1
anti-thymocyte globulin + Busulfan + Fludarabine Busulfan Fludarabine anti-thymocyte globulin 0 2
Busulfan Busulfan 0 12
Busulfan + Clofarabine + Cyclophosphamide + Gemcitabine + Mycophenolate mofetil + Rituximab + Tacrolimus + Vorinostat Busulfan Clofarabine Cyclophosphamide Gemcitabine Mycophenolate mofetil Rituximab Tacrolimus Vorinostat 0 1
Busulfan + Clofarabine + Cyclophosphamide + Gemcitabine + Mycophenolate mofetil + Tacrolimus + Vorinostat Busulfan Clofarabine Cyclophosphamide Gemcitabine Mycophenolate mofetil Tacrolimus Vorinostat 0 1
Busulfan + Clofarabine + Fludarabine Busulfan Clofarabine Fludarabine 0 1
Busulfan + Clofarabine + Gemcitabine Busulfan Clofarabine Gemcitabine 0 1
Busulfan + Cyclophosphamide Busulfan Cyclophosphamide 1 1
Busulfan + Cyclophosphamide + Etoposide Busulfan Cyclophosphamide Etoposide 0 1
Busulfan + Cyclophosphamide + Fludarabine Busulfan Cyclophosphamide Fludarabine 0 1
Busulfan + Cyclophosphamide + Gemtuzumab ozogamicin Busulfan Cyclophosphamide Gemtuzumab ozogamicin 0 1
Busulfan + Filgrastim + Fludarabine + Melphalan + MGTA-456 + Mycophenolate mofetil + Tacrolimus Busulfan Filgrastim Fludarabine MGTA-456 Melphalan Mycophenolate mofetil Tacrolimus 0 1
Busulfan + Fludarabine Busulfan Fludarabine 0 1
Busulfan + Fludarabine + GVAX + Methotrexate + Tacrolimus Busulfan Fludarabine GVAX Methotrexate Tacrolimus 0 1
Busulfan + Fludarabine + Methotrexate + Tacrolimus Busulfan Fludarabine Methotrexate Tacrolimus 0 1
Busulfan + Fludarabine + Romidepsin Busulfan Fludarabine Romidepsin 0 1
Busulfan + Fludarabine + Sorafenib Busulfan Fludarabine Sorafenib 0 1
Busulfan + Fludarabine + Venetoclax Busulfan Fludarabine Venetoclax 0 1
Busulfan + Gemcitabine + Melphalan + Panobinostat Busulfan Gemcitabine Melphalan Panobinostat 0 1
Busulfan + Hu14.18K322A Busulfan Hu14.18K322A 0 1
Busulfan + Melphalan Busulfan Melphalan 0 8
Busulfan + Venetoclax Busulfan Venetoclax 0 1


Additional content available in CKB BOOST