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Drug Name Busulfan
Trade Name Busulfex
Synonyms Busulphan
Drug Descriptions

Busulfex (busulfan) inhibits DNA replication and RNA transcription, likely through induction of DNA alkylation (PMID: 27481448). Busulfex (busulfan) in combination with cyclophosphamide is FDA approved as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for patients with chronic myelogenous leukemia (FDA.gov).

DrugClasses
CAS Registry Number 55-98-1
NCIT ID C321

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Therapy Name Drugs Efficacy Evidence Clinical Trials
anti-thymocyte globulin + Busulfan + Clofarabine Busulfan Clofarabine anti-thymocyte globulin 0 3
anti-thymocyte globulin + Busulfan + Clofarabine + Fludarabine + haNK cells Busulfan Clofarabine Fludarabine anti-thymocyte globulin haNK cells 0 1
anti-thymocyte globulin + Busulfan + Fludarabine Busulfan Fludarabine anti-thymocyte globulin 0 2
Busulfan Busulfan 0 13
Busulfan + Cladribine + Fludarabine + Thiotepa + Venetoclax Busulfan Cladribine Fludarabine Thiotepa Venetoclax 0 1
Busulfan + Clofarabine + Cyclophosphamide + Gemcitabine + Mycophenolate mofetil + Rituximab + Tacrolimus + Vorinostat Busulfan Clofarabine Cyclophosphamide Gemcitabine Mycophenolate mofetil Rituximab Tacrolimus Vorinostat 0 1
Busulfan + Clofarabine + Cyclophosphamide + Gemcitabine + Mycophenolate mofetil + Tacrolimus + Vorinostat Busulfan Clofarabine Cyclophosphamide Gemcitabine Mycophenolate mofetil Tacrolimus Vorinostat 0 1
Busulfan + Clofarabine + Fludarabine Busulfan Clofarabine Fludarabine 0 1
Busulfan + Clofarabine + Gemcitabine Busulfan Clofarabine Gemcitabine 0 1
Busulfan + CPX-351 + Fludarabine + Melphalan + Midostaurin Busulfan CPX-351 Fludarabine Melphalan Midostaurin 0 1
Busulfan + Cyclophosphamide Busulfan Cyclophosphamide 0 2
Busulfan + Cyclophosphamide + Etoposide Busulfan Cyclophosphamide Etoposide 0 1
Busulfan + Cyclophosphamide + Fludarabine Busulfan Cyclophosphamide Fludarabine 0 1
Busulfan + Cyclophosphamide + Gemtuzumab ozogamicin Busulfan Cyclophosphamide Gemtuzumab ozogamicin 0 1
Busulfan + Filgrastim + Fludarabine + Melphalan + MGTA-456 + Mycophenolate mofetil + Tacrolimus Busulfan Filgrastim Fludarabine MGTA-456 Melphalan Mycophenolate mofetil Tacrolimus 0 1
Busulfan + Fludarabine Busulfan Fludarabine 0 2
Busulfan + Fludarabine + GVAX + Methotrexate + Tacrolimus Busulfan Fludarabine GVAX Methotrexate Tacrolimus 0 1
Busulfan + Fludarabine + Methotrexate + Tacrolimus Busulfan Fludarabine Methotrexate Tacrolimus 0 1
Busulfan + Fludarabine + Romidepsin Busulfan Fludarabine Romidepsin 0 1
Busulfan + Fludarabine + Sorafenib Busulfan Fludarabine Sorafenib 0 1
Busulfan + Fludarabine + Venetoclax Busulfan Fludarabine Venetoclax 0 1
Busulfan + Gemcitabine + Melphalan + Panobinostat Busulfan Gemcitabine Melphalan Panobinostat 0 1
Busulfan + Hu14.18K322A Busulfan Hu14.18K322A 0 1
Busulfan + Melphalan Busulfan Melphalan 0 11
Busulfan + Melphalan + Thiotepa Busulfan Melphalan Thiotepa 0 1
Busulfan + Venetoclax Busulfan Venetoclax 0 1


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