Drug Detail

Drug Name Vorinostat
Trade Name Zolinza
Synonyms SAHA|L-001079038|MSK390
Drug Descriptions

Zolinza (vorinostat) inhibits HDAC activity, resulting in cell-cycle arrest, decreased proliferation, and increased differentiation of tumor cells (PMID: 9501205, PMID: 11731433, PMID: 11016644). Zolinza (vorinostat) is FDA approved for use in cutaneous T-cell lymphoma (FDA.gov).

DrugClasses HDAC Inhibitor 35

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Therapy Name Drugs Efficacy Evidence Clinical Trials
131I-MIBG + Vorinostat 131I-MIBG Vorinostat 1 1
ABT-737 + Vorinostat ABT-737 Vorinostat 0 0
Alvespimycin + Vorinostat Alvespimycin Vorinostat 1 0
Azacitidine + Gemcitabine + Vorinostat Azacitidine Gemcitabine Vorinostat 0 1
Azacitidine + Vorinostat Azacitidine Vorinostat 0 1
Bevacizumab + Vorinostat Bevacizumab Vorinostat 1 1
Bortezomib + Sorafenib + Vorinostat Bortezomib Sorafenib Vorinostat 0 1
Bortezomib + Vorinostat Bortezomib Vorinostat 1 0
Carboplatin + Paclitaxel + Vorinostat Carboplatin Paclitaxel Vorinostat 1 0
Doxorubicin + Vorinostat Doxorubicin Vorinostat 1 0
Etoposide + Vorinostat Etoposide Vorinostat 0 1
Fenretinide + Vorinostat Fenretinide Vorinostat 1 0
Gemcitabine + Nab-paclitaxel + Sorafenib + Vorinostat Gemcitabine Nab-paclitaxel Sorafenib Vorinostat 0 1
Hydroxychloroquine + Vorinostat Hydroxychloroquine Vorinostat 0 2
Ixazomib + Vorinostat Ixazomib Vorinostat 1 1
Lenalidomide + Vorinostat Lenalidomide Vorinostat 0 1
Marizomib + Vorinostat Marizomib Vorinostat 1 0
Olaparib + Vorinostat Olaparib Vorinostat 0 1
P10 + Vorinostat P10 Vorinostat 1 0
Paclitaxel + Vorinostat Paclitaxel Vorinostat 0 1
Palbociclib + Vorinostat Palbociclib Vorinostat 0 0
Pazopanib + Vorinostat Pazopanib Vorinostat 4 0
Pembrolizumab + Tamoxifen + Vorinostat Pembrolizumab Tamoxifen Vorinostat 0 1
Pembrolizumab + Temozolomide + Vorinostat Pembrolizumab Temozolomide Vorinostat 0 1
Pembrolizumab + Vorinostat Pembrolizumab Vorinostat 0 3
Pictilisib + Vorinostat Pictilisib Vorinostat 1 0
PLX4720 + Vorinostat PLX4720 Vorinostat 1 0
Sorafenib + Vorinostat Sorafenib Vorinostat 0 1
Tanespimycin + Vorinostat Tanespimycin Vorinostat 1 0
Temsirolimus + Vorinostat Temsirolimus Vorinostat 0 1
Tozasertib + Vorinostat Tozasertib Vorinostat 0 0
Vorinostat Vorinostat 9 30
Vorinostat + WP1066 Vorinostat WP1066 0 0