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Drug Name 131I-MIBG
Trade Name Azedra
Synonyms I131 Metaiodobenzylguanidine iodine|iobenguane I 131
Drug Descriptions

Azedra (iobenguane I 131) is a norepinephrine-like molecule labeled with radioactive I 131, which can be used to image or eliminate tumor cells overexpressing norepinephrine transporters (PMID: 25874239). Azedra (iobenguane I 131) is FDA approved for use in adult and pediatric patients 12 years and older with iobenguane scan positive pheochromocytoma or paraganglioma (FDA.gov).

DrugClasses
CAS Registry Number 77679-27-7
NCIT ID C82344

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Therapy Name Drugs Efficacy Evidence Clinical Trials
131I-MIBG 131I-MIBG 0 5
131I-MIBG + Dinutuximab + Sargramostim 131I-MIBG Dinutuximab Sargramostim 0 1
131I-MIBG + Dinutuximab + Sargramostim + Vorinostat 131I-MIBG Dinutuximab Sargramostim Vorinostat 0 1
131I-MIBG + Irinotecan + Vincristine Sulfate 131I-MIBG Irinotecan Vincristine Sulfate 0 1
131I-MIBG + lutetium Lu 177 dotatate 131I-MIBG lutetium Lu 177 dotatate 0 1
131I-MIBG + Vorinostat 131I-MIBG Vorinostat 0 2


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