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Drug Name Dinutuximab
Trade Name Unituxin
Synonyms MOAB Ch14.18
Drug Descriptions

Unituxin (dinutuximab) is a monoclonal antibody that targets B4GALNT1 (GD2) and increases antibody-dependent and complement-dependent cytotoxicity against GD2-expressing tumor cells (PMID: 26917818). Unituxin (dinutuximab) is FDA approved for pediatric high-risk neuroblastoma (FDA.gov).

DrugClasses
CAS Registry Number 1363687-32-4
NCIT ID C1570

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Therapy Name Drugs Efficacy Evidence Clinical Trials
131I-MIBG + Dinutuximab + Sargramostim 131I-MIBG Dinutuximab Sargramostim 0 1
131I-MIBG + Dinutuximab + Sargramostim + Vorinostat 131I-MIBG Dinutuximab Sargramostim Vorinostat 0 1
Aldesleukin + Dinutuximab + Zoledronic acid Aldesleukin Dinutuximab Zoledronic acid 0 1
Cisplatin + Cyclophosphamide + Dexrazoxane + Dinutuximab + Doxorubicin + Etoposide + Topotecan + Vincristine Sulfate Cisplatin Cyclophosphamide Dexrazoxane Dinutuximab Doxorubicin Etoposide Topotecan Vincristine Sulfate 0 1
Cisplatin + Dinutuximab + Etoposide Cisplatin Dinutuximab Etoposide 0 1
Cisplatin + Dinutuximab + Etoposide + Sargramostim Cisplatin Dinutuximab Etoposide Sargramostim 0 1
Cyclophosphamide + Dinutuximab + Doxorubicin + Sargramostim + Vincristine Sulfate Cyclophosphamide Dinutuximab Doxorubicin Sargramostim Vincristine Sulfate 0 1
Cyclophosphamide + Dinutuximab + Irinotecan + Sargramostim + Temozolomide + Topotecan Cyclophosphamide Dinutuximab Irinotecan Sargramostim Temozolomide Topotecan 0 1
Dinutuximab Dinutuximab 0 2
Dinutuximab + Eflornithine + Irinotecan + Sargramostim + Temozolomide Dinutuximab Eflornithine Irinotecan Sargramostim Temozolomide 0 1
Dinutuximab + Hu5F9-G4 Dinutuximab Hu5F9-G4 0 1
Dinutuximab + Irinotecan + Isotretinoin + Sargramostim + Temozolomide Dinutuximab Irinotecan Isotretinoin Sargramostim Temozolomide 0 1
Dinutuximab + Irinotecan + Sargramostim + Temozolomide Dinutuximab Irinotecan Sargramostim Temozolomide 0 2
Dinutuximab + Irinotecan + Temozolomide Dinutuximab Irinotecan Temozolomide 0 1
Dinutuximab + Isotretinoin Dinutuximab Isotretinoin 0 1
Dinutuximab + Isotretinoin + Sargramostim Dinutuximab Isotretinoin Sargramostim 0 1
Dinutuximab + Lenalidomide Dinutuximab Lenalidomide 0 1
Dinutuximab + Sargramostim Dinutuximab Sargramostim 0 0


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