Drug Detail


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Drug Name Hu5F9-G4
Trade Name
Synonyms Magrolimab|Hu5F9 G4|GS-4721
Drug Descriptions

Magrolimab (Hu5F9-G4) is a humanized monoclonal antibody against CD47 that binds to and blocks CD47 downstream signaling and subsequent activation of the SIRPa receptor on macrophages, leading to phagocytosis of tumor cells (PMID: 26390038, PMID: 28286286) and may also stimulate cytotoxic T-cells (PMID: 29873856).

DrugClasses CD47 Antibody 16 Immune Checkpoint Inhibitor 135
CAS Registry Number 2169232-81-7
NCIT ID C117730


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Hu5F9-G4 Atezolizumab Hu5F9-G4 0 2
Avelumab + Hu5F9-G4 Avelumab Hu5F9-G4 0 1
Azacitidine + Hu5F9-G4 Azacitidine Hu5F9-G4 1 4
Azacitidine + Hu5F9-G4 + Venetoclax Azacitidine Hu5F9-G4 Venetoclax 0 2
Bortezomib + Dexamethasone + Hu5F9-G4 Bortezomib Dexamethasone Hu5F9-G4 0 1
Carboplatin + Fluorouracil + Hu5F9-G4 + Pembrolizumab Carboplatin Fluorouracil Hu5F9-G4 Pembrolizumab 0 1
Cetuximab + Hu5F9-G4 Cetuximab Hu5F9-G4 0 1
Cisplatin + Fluorouracil + Hu5F9-G4 + Pembrolizumab Cisplatin Fluorouracil Hu5F9-G4 Pembrolizumab 0 1
Cytarabine + Etoposide + Hu5F9-G4 + Mitoxantrone Cytarabine Etoposide Hu5F9-G4 Mitoxantrone 0 1
Daratumumab + Hu5F9-G4 Daratumumab Hu5F9-G4 0 1
Dexamethasone + Hu5F9-G4 + Pomalidomide Dexamethasone Hu5F9-G4 Pomalidomide 0 1
Dinutuximab + Hu5F9-G4 Dinutuximab Hu5F9-G4 0 1
Docetaxel + Hu5F9-G4 Docetaxel Hu5F9-G4 0 2
Hu5F9-G4 Hu5F9-G4 0 3
Hu5F9-G4 + Mogamulizumab Hu5F9-G4 Mogamulizumab 0 1
Hu5F9-G4 + Nab-paclitaxel Hu5F9-G4 Nab-paclitaxel 0 1
Hu5F9-G4 + Obinutuzumab + Venetoclax Hu5F9-G4 Obinutuzumab Venetoclax 0 1
Hu5F9-G4 + Paclitaxel Hu5F9-G4 Paclitaxel 0 1
Hu5F9-G4 + Pembrolizumab Hu5F9-G4 Pembrolizumab 0 2
Hu5F9-G4 + Rituximab Hu5F9-G4 Rituximab 0 1

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