Therapy Detail
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| Therapy Name | Hu5F9-G4 |
| Synonyms | |
| Therapy Description |
Magrolimab (Hu5F9-G4) is a humanized monoclonal antibody against CD47 that binds to and blocks CD47 downstream signaling and subsequent activation of the SIRPa receptor on macrophages, leading to phagocytosis of tumor cells (PMID: 26390038, PMID: 28286286) and may also stimulate cytotoxic T-cells (PMID: 29873856). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Hu5F9-G4 | Magrolimab|Hu5F9 G4|GS-4721 | CD47 Antibody 30 Immune Checkpoint Inhibitor 147 | Magrolimab (Hu5F9-G4) is a humanized monoclonal antibody against CD47 that binds to and blocks CD47 downstream signaling and subsequent activation of the SIRPa receptor on macrophages, leading to phagocytosis of tumor cells (PMID: 26390038, PMID: 28286286) and may also stimulate cytotoxic T-cells (PMID: 29873856). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05169944 | Phase I | Hu5F9-G4 | Magrolimab in Children and Adults With Recurrent or Progressive Malignant Brain Tumors (PNOC025) | Suspended | USA | 0 |
| NCT03248479 | Phase I | Azacitidine + Hu5F9-G4 Hu5F9-G4 | Hu5F9-G4 Monotherapy or Hu5F9-G4 in Combination With Azacitidine in Patients With Hematological Malignancies | Terminated | USA | GBR | 0 |
| NCT04541017 | Phase Ib/II | Hu5F9-G4 Hu5F9-G4 + Mogamulizumab | Testing the Addition of an Anti-cancer Drug, Hu5F9-G4 (Magrolimab), to the Usual Chemotherapy Treatment (Mogamulizumab) in T-Cell (a Type of Immune Cell) Lymphoma That Has Returned After Treatment or Does Not Respond to Treatment | Active, not recruiting | USA | 0 |
| NCT02216409 | Phase I | Hu5F9-G4 | Phase 1 Trial of Hu5F9-G4, a CD47-targeting Antibody | Completed | USA | 0 |
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