Drug Detail


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Drug Name Mogamulizumab
Trade Name Poteligeo
Synonyms KW-0761|Mogamulizumab-kpkc
Drug Descriptions

Poteligeo (mogamulizumab-kpkc) is a monoclonal antibody that binds to and inhibits C-C chemokine receptor 4 (CCR4) signaling, which leads to inhibition of Tregs and enhancement of host antitumor immunity (PMID: 25496334). Poteligeo (mogamulizumab-kpkc) is FDA approved for adult patients with relapsed or refractory mycosis fungoides or Sezary syndrome (FDA.gov).

CAS Registry Number 1159266-37-1
NCIT ID C62510


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Brentuximab vedotin + Mogamulizumab Brentuximab vedotin Mogamulizumab 0 1
Cyclophosphamide + Doxorubicin + Etoposide + Mogamulizumab + Prednisone + Vincristine Sulfate Cyclophosphamide Doxorubicin Etoposide Mogamulizumab Prednisone Vincristine Sulfate 0 1
Durvalumab + Mogamulizumab Durvalumab Mogamulizumab 0 0
Hu5F9-G4 + Mogamulizumab Hu5F9-G4 Mogamulizumab 0 1
KHK2455 + Mogamulizumab KHK2455 Mogamulizumab 0 1
Mogamulizumab Mogamulizumab 0 9
Mogamulizumab + Nivolumab Mogamulizumab Nivolumab 0 1
Mogamulizumab + Pembrolizumab Mogamulizumab Pembrolizumab 0 2
Mogamulizumab + rhIL-15 Mogamulizumab rhIL-15 0 1
Mogamulizumab + Tremelimumab Mogamulizumab Tremelimumab 0 0
Mogamulizumab + Utomilumab Mogamulizumab Utomilumab 0 1

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