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| Drug Name | Tremelimumab |
| Trade Name | Imjudo |
| Synonyms | CP-675,206|Ticilimumab|CP-675206 |
| Drug Descriptions |
Imjudo (tremelimumab) binds to and inhibits cytotoxic T-lymphocyte-associated protein 4 (CTLA4), thereby enhancing T-cell activation by blocking CTLA4-mediated inhibition of T-cell activation (PMID: 32620213, PMID: 32586937). Imjudo (tremelimumab) is FDA approved for use in combination with Imfinzi (durvalumab) in adult patients with unresectable hepatocellular carcinoma, and in combination with Imfinzi (durvalumab) and platinum-based chemotherapy in patients with metastatic non-small cell lung cancer (NSCLC) without sensitizing EGFR or ALK mutations (FDA.gov). |
| DrugClasses | CTLA4 Antibody 29 Immune Checkpoint Inhibitor 147 |
| CAS Registry Number | 745013-59-6 |
| NCIT ID | C49085 |
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