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Drug Name Guadecitabine
Trade Name
Synonyms S110|DNMT inhibitor SGI-110
Drug Descriptions

Guadecitabine (SGI-110) is a dinucleotide comprised of decitabine and deoxyguanosine, which inhibits DNA methylation, potentially resulting in decreased tumor cell growth (PMID: 20442312, PMID: 17616700).

DrugClasses DNMT inhibitor (Pan) 5

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + DEC-205-NY-ESO-1 fusion protein vaccine + Guadecitabine Atezolizumab DEC-205-NY-ESO-1 fusion protein vaccine Guadecitabine 0 1
Atezolizumab + Guadecitabine Atezolizumab Guadecitabine 0 4
Carboplatin + Guadecitabine Carboplatin Guadecitabine 0 1
Durvalumab + Guadecitabine Durvalumab Guadecitabine 0 2
Durvalumab + Guadecitabine + Tremelimumab Durvalumab Guadecitabine Tremelimumab 0 1
Guadecitabine Guadecitabine 2 12
Guadecitabine + Irinotecan Guadecitabine Irinotecan 0 1
Guadecitabine + Mocetinostat + Pembrolizumab Guadecitabine Mocetinostat Pembrolizumab 0 1
Guadecitabine + Nivolumab Guadecitabine Nivolumab 0 1
Guadecitabine + Pembrolizumab Guadecitabine Pembrolizumab 0 1


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