Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Guadecitabine
Trade Name
Synonyms S110|SGI-110
Drug Descriptions

Guadecitabine (SGI-110) is a dinucleotide comprised of decitabine and deoxyguanosine, which inhibits DNA methylation, potentially resulting in decreased tumor cell growth (PMID: 20442312, PMID: 17616700, PMID: 32655143).

DrugClasses DNMT inhibitor (Pan) 5
CAS Registry Number 929901-49-5
NCIT ID C95209

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Guadecitabine Atezolizumab Guadecitabine 0 4
Atezolizumab + Guadecitabine + Rasdegafusp alfa Atezolizumab Guadecitabine Rasdegafusp alfa 0 1
Belinostat + Guadecitabine Belinostat Guadecitabine 0 1
Carboplatin + Guadecitabine Carboplatin Guadecitabine 0 1
Durvalumab + Guadecitabine Durvalumab Guadecitabine 0 2
Durvalumab + Guadecitabine + Tremelimumab Durvalumab Guadecitabine Tremelimumab 0 1
Guadecitabine Guadecitabine 0 12
Guadecitabine + Ipilimumab + Nivolumab Guadecitabine Ipilimumab Nivolumab 0 1
Guadecitabine + Irinotecan Guadecitabine Irinotecan 0 1
Guadecitabine + Mocetinostat + Pembrolizumab Guadecitabine Mocetinostat Pembrolizumab 0 1
Guadecitabine + Nivolumab Guadecitabine Nivolumab 0 1
Guadecitabine + Pembrolizumab Guadecitabine Pembrolizumab 0 2


Additional content available in CKB BOOST