Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Lenvatinib
Trade Name Lenvima
Synonyms E7080
Drug Descriptions

Lenvima (lenvatinib) inhibits VEGFR, FGFR, PDGFR, KIT, and RET, and suppresses cell proliferation and angiogenesis (PMID: 21781317, PMID: 25295214, PMID: 17943726). Lenvima (lenvatinib) is FDA approved for use in patients with radioactive iodine-refractory differentiated thyroid cancer, unresectable hepatocellular carcinoma, in combination with Keytruda (pembrolizumab) as first line, or with Afinitor (everolimus) for renal cell carcinoma, and in combination with Pembrolizumab for endometrial carcinoma that is not MSI-H or dMMR (FDA.gov).

DrugClasses FGFR Inhibitor (Pan) 19 KIT Inhibitor 51 PDGFR Inhibitor (Pan) 27 RET Inhibitor 39 VEGFR Inhibitor (Pan) 32
CAS Registry Number 417716-92-8
NCIT ID C95124

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
AK104 + Lenvatinib AK104 Lenvatinib 0 0
Atezolizumab + Lenvatinib Atezolizumab Lenvatinib 0 1
Belzutifan + Lenvatinib Belzutifan Lenvatinib 0 2
Belzutifan + Lenvatinib + Pembrolizumab Belzutifan Lenvatinib Pembrolizumab 0 3
Camrelizumab + Lenvatinib Camrelizumab Lenvatinib 0 0
Capecitabine + Fluorouracil + Lenvatinib + Leucovorin + Oxaliplatin + Pembrolizumab Capecitabine Fluorouracil Lenvatinib Leucovorin Oxaliplatin Pembrolizumab 0 1
Capecitabine + Lenvatinib Capecitabine Lenvatinib 0 2
Carboplatin + Etoposide + Lenvatinib + Pembrolizumab Carboplatin Etoposide Lenvatinib Pembrolizumab 0 1
Carboplatin + Lenvatinib + Paclitaxel Carboplatin Lenvatinib Paclitaxel 0 0
Carboplatin + Lenvatinib + Paclitaxel + Pembrolizumab Carboplatin Lenvatinib Paclitaxel Pembrolizumab 0 1
Carboplatin + Lenvatinib + Pembrolizumab + Pemetrexed Disodium Carboplatin Lenvatinib Pembrolizumab Pemetrexed Disodium 0 1
Cetuximab + Lenvatinib Cetuximab Lenvatinib 0 1
Cisplatin + Etoposide + Lenvatinib + Pembrolizumab Cisplatin Etoposide Lenvatinib Pembrolizumab 0 1
Cisplatin + Fluorouracil + Lenvatinib + Pembrolizumab Cisplatin Fluorouracil Lenvatinib Pembrolizumab 0 1
Cisplatin + Lenvatinib + Pembrolizumab + Pemetrexed Disodium Cisplatin Lenvatinib Pembrolizumab Pemetrexed Disodium 0 1
Denosumab + Lenvatinib Denosumab Lenvatinib 0 1
Eribulin + Lenvatinib Eribulin Lenvatinib 0 1
Erlotinib + Lenvatinib Erlotinib Lenvatinib 0 0
Etoposide + Ifosfamide + Lenvatinib Etoposide Ifosfamide Lenvatinib 0 1
Everolimus + Lenvatinib Everolimus Lenvatinib 0 8
Fluorouracil + Lenvatinib + Leucovorin + Oxaliplatin + Pembrolizumab Fluorouracil Lenvatinib Leucovorin Oxaliplatin Pembrolizumab 0 1
FRAX1036 + Lenvatinib FRAX1036 Lenvatinib 0 0
Gefitinib + Lenvatinib Gefitinib Lenvatinib 0 0
Lenvatinib Lenvatinib 9 23
Lenvatinib + Midazolam Lenvatinib Midazolam 0 1
Lenvatinib + MK-1308 + Pembrolizumab Lenvatinib MK-1308 Pembrolizumab 0 1
Lenvatinib + MK-1308A Lenvatinib MK-1308A 0 5
Lenvatinib + MK-4280A Lenvatinib MK-4280A 0 1
Lenvatinib + MK-7684A Lenvatinib MK-7684A 0 0
Lenvatinib + Nivolumab Lenvatinib Nivolumab 0 1
Lenvatinib + Paclitaxel Lenvatinib Paclitaxel 0 1
Lenvatinib + Paclitaxel + Pembrolizumab Lenvatinib Paclitaxel Pembrolizumab 0 1
Lenvatinib + Pembrolizumab Lenvatinib Pembrolizumab 0 39
Lenvatinib + Sorafenib Lenvatinib Sorafenib 0 2
Lenvatinib + XMD8-92 Lenvatinib XMD8-92 0 0


Additional content available in CKB BOOST