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Drug Name Lenvatinib
Trade Name Lenvima
Synonyms E7080
Drug Descriptions

Lenvima (lenvatinib) inhibits VEGFR, FGFR, PDGFR, KIT, and RET, and suppresses cell proliferation and angiogenesis (PMID: 21781317, PMID: 25295214, PMID: 17943726). Lenvima (lenvatinib) is FDA approved for use in patients with radioactive iodine-refractory differentiated thyroid cancer, unresectable hepatocellular carcinoma, in combination with Afinitor (everolimus) for renal cell carcinoma, and in combination with Pembrolizumab for endometrial carcinoma that is not MSI-H or dMMR (FDA.gov).

DrugClasses FGFR Inhibitor (Pan) 18 KIT Inhibitor 50 PDGFR Inhibitor (Pan) 27 RET Inhibitor 39 VEGFR Inhibitor (Pan) 32

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Capecitabine + Lenvatinib Capecitabine Lenvatinib 0 2
Carboplatin + Lenvatinib + Paclitaxel Carboplatin Lenvatinib Paclitaxel 1 0
Carboplatin + Lenvatinib + Pembrolizumab + Pemetrexed Carboplatin Lenvatinib Pembrolizumab Pemetrexed 0 1
Cetuximab + Lenvatinib Cetuximab Lenvatinib 0 1
Cisplatin + Lenvatinib + Pembrolizumab + Pemetrexed Cisplatin Lenvatinib Pembrolizumab Pemetrexed 0 1
Eribulin + Lenvatinib Eribulin Lenvatinib 0 1
Everolimus + Lenvatinib Everolimus Lenvatinib 2 7
Lenvatinib Lenvatinib 24 19
Lenvatinib + Midazolam Lenvatinib Midazolam 0 1
Lenvatinib + Paclitaxel Lenvatinib Paclitaxel 0 1
Lenvatinib + Pembrolizumab Lenvatinib Pembrolizumab 7 20
Lenvatinib + Sorafenib Lenvatinib Sorafenib 0 1


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