Drug Detail


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Drug Name Lenvatinib
Trade Name Lenvima
Synonyms E7080
Drug Descriptions

Lenvima (lenvatinib) inhibits VEGFR, FGFR, PDGFR, KIT, and RET, and suppresses cell proliferation and angiogenesis (PMID: 21781317, PMID: 25295214, PMID: 17943726). Lenvima (lenvatinib) is FDA approved for use in patients with radioactive iodine-refractory differentiated thyroid cancer, unresectable hepatocellular carcinoma, in combination with Afinitor (everolimus) for renal cell carcinoma, and in combination with Pembrolizumab for endometrial carcinoma that is not MSI-H or dMMR (FDA.gov).

DrugClasses FGFR Inhibitor (Pan) 18 KIT Inhibitor 51 PDGFR Inhibitor (Pan) 27 RET Inhibitor 39 VEGFR Inhibitor (Pan) 32
CAS Registry Number 417716-92-8
NCIT ID C95124


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Camrelizumab + Lenvatinib Camrelizumab Lenvatinib 0 0
Capecitabine + Lenvatinib Capecitabine Lenvatinib 0 2
Carboplatin + Lenvatinib + Paclitaxel Carboplatin Lenvatinib Paclitaxel 1 0
Carboplatin + Lenvatinib + Pembrolizumab + Pemetrexed Disodium Carboplatin Lenvatinib Pembrolizumab Pemetrexed Disodium 0 1
Cetuximab + Lenvatinib Cetuximab Lenvatinib 0 1
Cisplatin + Lenvatinib + Pembrolizumab + Pemetrexed Disodium Cisplatin Lenvatinib Pembrolizumab Pemetrexed Disodium 0 1
Eribulin + Lenvatinib Eribulin Lenvatinib 0 1
Etoposide + Ifosfamide + Lenvatinib Etoposide Ifosfamide Lenvatinib 0 1
Everolimus + Lenvatinib Everolimus Lenvatinib 2 7
Lenvatinib Lenvatinib 25 21
Lenvatinib + Midazolam Lenvatinib Midazolam 0 1
Lenvatinib + MK-1308 + Pembrolizumab Lenvatinib MK-1308 Pembrolizumab 0 1
Lenvatinib + MK-1308A Lenvatinib MK-1308A 0 1
Lenvatinib + MK-4280A Lenvatinib MK-4280A 0 1
Lenvatinib + Paclitaxel Lenvatinib Paclitaxel 0 1
Lenvatinib + Pembrolizumab Lenvatinib Pembrolizumab 9 25
Lenvatinib + Pembrolizumab + PT 2977 Lenvatinib PT 2977 Pembrolizumab 0 1
Lenvatinib + PT 2977 Lenvatinib PT 2977 0 2
Lenvatinib + Sorafenib Lenvatinib Sorafenib 0 1

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