Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name MK-4280
Trade Name
Synonyms MK4280|MK 4280|favezelimab
Drug Descriptions

MK-4280 (favezelimab) is a monoclonal antibody that targets LAG3 and inhibits binding of MHC II molecules to increase cytokine production by T-cells and prevent tumor growth (PMID: 29359507, PMID: 29427592).

DrugClasses Immune Checkpoint Inhibitor 147 LAG3 Antibody 18
CAS Registry Number 2231068-83-8
NCIT ID C142077


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Irinotecan + MK-4280 + Pembrolizumab Irinotecan MK-4280 Pembrolizumab 0 0
Lenvatinib + MK-4280 + Pembrolizumab Lenvatinib MK-4280 Pembrolizumab 0 0
MK-4280 MK-4280 0 1
MK-4280 + Paclitaxel + Pembrolizumab MK-4280 Paclitaxel Pembrolizumab 0 0
MK-4280 + Pembrolizumab MK-4280 Pembrolizumab 0 3

Additional content available in CKB BOOST