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Drug Name MK-4280
Trade Name
Synonyms MK4280|MK 4280|favezelimab
Drug Descriptions

MK-4280 (favezelimab) is a monoclonal antibody that targets LAG3 and inhibits binding of MHC II molecules to increase cytokine production by T-cells and prevent tumor growth (PMID: 29359507, PMID: 29427592).

DrugClasses Immune Checkpoint Inhibitor 146 LAG3 Antibody 18
CAS Registry Number 2231068-83-8
NCIT ID C142077

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Irinotecan + MK-4280 + Pembrolizumab Irinotecan MK-4280 Pembrolizumab 0 0
Lenvatinib + MK-4280 + Pembrolizumab Lenvatinib MK-4280 Pembrolizumab 0 0
MK-4280 MK-4280 0 1
MK-4280 + Paclitaxel + Pembrolizumab MK-4280 Paclitaxel Pembrolizumab 0 0
MK-4280 + Pembrolizumab MK-4280 Pembrolizumab 0 3


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