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Drug Name CB-103
Trade Name
Synonyms CB103|CB 103
Drug Descriptions

CB-103 is a small molecule inhibitor of NOTCH signaling via inhibition of the NOTCH transcriptional activation complex, which may result in antitumor efficacy (Cancer Res 2016;76(14 Suppl):Abstract nr 338, PMID: 32601208).

DrugClasses NOTCH Inhibitor (Pan) 5
CAS Registry Number HY-135145
NCIT ID C175580


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + CB-103 Abemaciclib CB-103 0 1
Anastrozole + CB-103 Anastrozole CB-103 0 1
CB-103 CB-103 0 1
CB-103 + Lenvatinib CB-103 Lenvatinib 0 1
CB-103 + Letrozole CB-103 Letrozole 0 1
CB-103 + Venetoclax CB-103 Venetoclax 0 1

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