Drug Detail


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Drug Name MK-7684A
Trade Name
Synonyms MK-7684/MK-3475|Vibostolimab/Pembrolizumab
Drug Descriptions

MK-7684A is a co-formulation of the immune checkpoint inhibitor Keytruda (pembrolizumab) and MK-7684 (Vibostolimab), an antibody directed against T-cell immunoreceptor with Ig and ITIM domains (TIGIT), which may lead to the activation of immune response against tumor cells (NCI Drug Dictionary).

DrugClasses Immune Checkpoint Inhibitor 151 PD-L1/PD-1 antibody 98 TIGIT Antibody 17
CAS Registry Number NA
NCIT ID C176841


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + Etoposide + MK-7684A Carboplatin Etoposide MK-7684A 0 1
Carboplatin + MK-7684A + Nab-paclitaxel Carboplatin MK-7684A Nab-paclitaxel 0 1
Carboplatin + MK-7684A + Paclitaxel Carboplatin MK-7684A Paclitaxel 0 2
Carboplatin + MK-7684A + Pemetrexed Disodium Carboplatin MK-7684A Pemetrexed Disodium 0 1
Cisplatin + Etoposide + MK-7684A Cisplatin Etoposide MK-7684A 0 2
Cisplatin + Fluorouracil + MK-7684A Cisplatin Fluorouracil MK-7684A 0 1
Cisplatin + MK-7684A + Pemetrexed Disodium Cisplatin MK-7684A Pemetrexed Disodium 0 2
Docetaxel + MK-7684A Docetaxel MK-7684A 0 1
Lenvatinib + MK-7684A Lenvatinib MK-7684A 0 1
MK-7684A MK-7684A 0 4
MK-7684A + Paclitaxel MK-7684A Paclitaxel 0 1

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