Drug Detail


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Drug Name Denosumab
Trade Name Xgeva
Synonyms AMG162|AMG-162|AMG 162|Prolia
Drug Descriptions

Xgeva (denosumab) is an antibody that binds to RANKL protein, inhibiting osteoclast activity and is FDA approved for use in patients with giant cell tumor of the bone (FDA.gov).

CAS Registry Number 615258-40-7
NCIT ID C61313


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Denosumab + Enzalutamide + Prednisone Abiraterone Denosumab Enzalutamide Prednisone 0 1
Capecitabine + Denosumab Capecitabine Denosumab 0 2
Carboplatin + Cisplatin + Denosumab + Gemcitabine Carboplatin Cisplatin Denosumab Gemcitabine 0 1
Crizotinib + Denosumab Crizotinib Denosumab 0 0
Denosumab Denosumab 0 11
Denosumab + Ensartinib Denosumab Ensartinib 0 0
Denosumab + Enzalutamide Denosumab Enzalutamide 0 1
Denosumab + Everolimus Denosumab Everolimus 0 1
Denosumab + Gemcitabine Denosumab Gemcitabine 0 1
Denosumab + Ipilimumab + Nivolumab Denosumab Ipilimumab Nivolumab 0 1
Denosumab + Lenvatinib Denosumab Lenvatinib 0 1
Denosumab + Nivolumab Denosumab Nivolumab 0 1
Denosumab + Nivolumab + RXC004 Denosumab Nivolumab RXC004 0 1
Denosumab + Paclitaxel Denosumab Paclitaxel 0 0
Denosumab + pamidronate + Zoledronic acid Denosumab Zoledronic acid pamidronate 0 1
Denosumab + Pembrolizumab Denosumab Pembrolizumab 0 2
Denosumab + Pembrolizumab + RXC004 Denosumab Pembrolizumab RXC004 0 1
Denosumab + Radium Ra 223 dichloride Denosumab Radium Ra 223 dichloride 0 1
Denosumab + RXC004 Denosumab RXC004 0 2
Denosumab + Sorafenib Denosumab Sorafenib 1 0
Denosumab + Zoledronic acid Denosumab Zoledronic acid 0 0

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