Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Denosumab
Trade Name Xgeva
Synonyms AMG162|AMG-162|AMG 162|Prolia
Drug Descriptions

Xgeva (denosumab) is an antibody that binds to RANKL protein, inhibiting osteoclast activity and is FDA approved for use in patients with giant cell tumor of the bone (FDA.gov).

DrugClasses

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Denosumab + Enzalutamide + Prednisone Abiraterone Denosumab Enzalutamide Prednisone 0 1
Carboplatin + Cisplatin + Denosumab + Gemcitabine Carboplatin Cisplatin Denosumab Gemcitabine 0 1
Denosumab Denosumab 1 10
Denosumab + Enzalutamide Denosumab Enzalutamide 0 1
Denosumab + Everolimus Denosumab Everolimus 0 1
Denosumab + pamidronate + Zoledronic acid Denosumab Zoledronic acid pamidronate 0 1
Denosumab + Pembrolizumab Denosumab Pembrolizumab 0 1
Denosumab + Radium Ra 223 dichloride Denosumab Radium Ra 223 dichloride 0 1
Denosumab + Zoledronic acid Denosumab Zoledronic acid 0 0


Additional content available in CKB BOOST