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Drug Name Belzutifan
Trade Name Welireg
Synonyms PT2977|MK-6482|PT-2977
Drug Descriptions

Welireg (belzutifan) is a hypoxia inducible factor-2alpha (EPAS1, HIF2A) inhibitor that suppresses expression of HIF2A target genes, resulting in tumor regression (Mol Cancer Ther 2018,17(1 Suppl):Abstract nr B140, PMID: 31282155). Welireg (belzutifan) is FDA-approved for use in patients with von Hippel-Lindau (VHL) disease-associated renal cell carcinoma, central nervous system hemangioblastomas, or pancreatic neuroendocrine tumors that require therapy, and in patients with advanced renal cell carcinoma who have received anti-PD-1 or PD-L1 therapy and VEGF inhibitor (FDA.gov).

DrugClasses HIF2A Inhibitor 6
CAS Registry Number 1672668-24-4
NCIT ID C135627


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Belzutifan Abemaciclib Belzutifan 0 1
Belzutifan Belzutifan 7 7
Belzutifan + Cabozantinib Belzutifan Cabozantinib 0 1
Belzutifan + HC-7366 Belzutifan HC-7366 0 1
Belzutifan + Lenvatinib Belzutifan Lenvatinib 0 2
Belzutifan + Lenvatinib + Pembrolizumab Belzutifan Lenvatinib Pembrolizumab 0 3
Belzutifan + Palbociclib Belzutifan Palbociclib 0 1
Belzutifan + Pembrolizumab Belzutifan Pembrolizumab 0 2
Belzutifan + PRT1419 Belzutifan PRT1419 0 0

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