Therapy Detail
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| Therapy Name | KN046 + Lenvatinib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| KN046 | KN 046|KN-046|Erfonrilimab | CTLA4 Antibody 24 Immune Checkpoint Inhibitor 153 PD-L1/PD-1 antibody 100 | KN046 is a bispecific monoclonal antibody that targets PD-L1 (CD274) expressed on tumor cells and CTLA-4 on T lymphocytes, potentially leading to enhanced antitumor immune response (NCI Drug Dictionary). | |
| Lenvatinib | Lenvima | E7080 | FGFR Inhibitor (Pan) 24 KIT Inhibitor 55 PDGFR Inhibitor (Pan) 28 RET Inhibitor 48 VEGFR Inhibitor (Pan) 34 | Lenvima (lenvatinib) inhibits VEGFR, FGFR, PDGFR, KIT, and RET, and suppresses cell proliferation and angiogenesis (PMID: 21781317, PMID: 25295214, PMID: 17943726). Lenvima (lenvatinib) is FDA approved for use in patients with radioactive iodine-refractory differentiated thyroid cancer, unresectable hepatocellular carcinoma, in combination with Keytruda (pembrolizumab) as first line, or with Afinitor (everolimus) for renal cell carcinoma, and in combination with Pembrolizumab for endometrial carcinoma that is not MSI-H or dMMR (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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