Drug Detail


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Drug Name Eflornithine
Trade Name Iwilfin
Synonyms DFMO|alpha-difluoromethylornithine
Drug Descriptions

Iwilfin (eflornithine) is an ornithine decarboxylase inhibitor that blocks polyamine production, resulting in reduced tumor cell proliferation (PMID: 32256343). Iwilfin (eflornithine) is FDA-approved for use in adult and pediatric patients with high-risk neuroblastoma who have responded to prior therapies (FDA.gov)

CAS Registry Number 70052-12-9


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Therapy Name Drugs Efficacy Evidence Clinical Trials
AMXT1501 + Eflornithine AMXT1501 Eflornithine 0 2
Dinutuximab + Eflornithine + Irinotecan + Sargramostim + Temozolomide Dinutuximab Eflornithine Irinotecan Sargramostim Temozolomide 0 1
Eflornithine Eflornithine 0 4
Eflornithine + Etoposide Eflornithine Etoposide 0 1
Eflornithine + Pembrolizumab Eflornithine Pembrolizumab 0 1
Eflornithine + SAM486 Eflornithine SAM486 0 0
Eflornithine + Testosterone cypionate Eflornithine Testosterone cypionate 0 1

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