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Therapy Name 131I-MIBG
Synonyms
Therapy Description

Azedra (iobenguane I 131) is a norepinephrine-like molecule labeled with radioactive I 131, which can be used to image or eliminate tumor cells overexpressing norepinephrine transporters (PMID: 25874239). Azedra (iobenguane I 131) is FDA approved for use in adult and pediatric patients 12 years and older with iobenguane scan positive pheochromocytoma or paraganglioma (FDA.gov).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
131I-MIBG Azedra I131 Metaiodobenzylguanidine iodine|iobenguane I 131 Azedra (iobenguane I 131) is a norepinephrine-like molecule labeled with radioactive I 131, which can be used to image or eliminate tumor cells overexpressing norepinephrine transporters (PMID: 25874239). Azedra (iobenguane I 131) is FDA approved for use in adult and pediatric patients 12 years and older with iobenguane scan positive pheochromocytoma or paraganglioma (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01175356 Phase I Busulfan + Melphalan Cyclophosphamide + Topotecan 131I-MIBG Cyclophosphamide + Doxorubicin + Vincristine Sulfate Cisplatin + Etoposide Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin Active, not recruiting USA 0
NCT02378428 Phase II 131I-MIBG MIBG Therapy for Patients With MIBG Avid Tumors Active, not recruiting USA 0
NCT03561259 Phase II 131I-MIBG + Vorinostat 131I-MIBG A Study of Therapeutic Iobenguane (131-I) and Vorinostat for Recurrent or Progressive High-Risk Neuroblastoma Subjects (OPTIMUM) Recruiting USA 0
NCT02035137 Phase II 131I-MIBG 131I-MIBG + Irinotecan + Vincristine Sulfate 131I-MIBG + Vorinostat 131I-MIBG Alone VS. 131I-MIBG With Vincristine and Irinotecan VS131I-MIBG With Vorinistat (N2011-01) Completed USA | CAN 0
NCT03126916 Phase III Doxorubicin 131I-MIBG Sargramostim Etoposide Melphalan Busulfan Isotretinoin Vincristine Sulfate Cisplatin Cyclophosphamide Thiotepa Dexrazoxane Lorlatinib Carboplatin Aldesleukin Topotecan Dinutuximab Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL) Active, not recruiting USA | CAN 1


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