Therapy Detail
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| Therapy Name | Sargramostim |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Sargramostim | Leukine | GM-CSF|Prokine |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status |
|---|---|---|---|---|
| NCT02411786 | Phase I | pTVG-AR Sargramostim | A Phase I Study of a DNA Vaccine Encoding Androgen Receptor Ligand-Binding Domain (AR LBD) +/-GMCSF | Active, not recruiting |
| NCT02297698 | Phase II | Sargramostim Trastuzumab E75 | Phase II Trial of Combination Immunotherapy With NeuVax and Trastuzumab in High-risk HER2+ Breast Cancer Patients | Active, not recruiting |
| NCT02510950 | Phase I | Sargramostim Poly ICLC Temozolomide | Neoepitope-based Personalized Vaccine Approach in Patients With Newly Diagnosed Glioblastoma | Terminated |
| NCT02636582 | Phase II | Sargramostim Nelipepimut-S Plus GM-CSF | Nelipepimut-S Plus GM-CSF Vaccine Therapy in Treating Patients With Breast Cancer | Active, not recruiting |
| NCT01857934 | Phase II | Doxorubicin Sargramostim Aldesleukin Vincristine Sulfate Filgrastim Tretinoin Levetiracetam Cisplatin + Etoposide Hu14.18K322A Busulfan + Melphalan Cyclophosphamide + Topotecan | Therapy for Children With Advanced Stage Neuroblastoma | Active, not recruiting |
| NCT01570036 | Phase II | E75 Sargramostim Trastuzumab | Combination Immunotherapy With Herceptin and the HER2 Vaccine NeuVax | Completed |
| NCT02620865 | Phase Ib/II | Paclitaxel Aldesleukin Oxaliplatin Sargramostim Gemcitabine Fluorouracil + Leucovorin | Bispecific Antibody Armed Activated T-cells With Aldesleukin and Sargramostim in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer | Active, not recruiting |
| NCT02009397 | Phase Ib/II | Sargramostim Ipilimumab | A Phase I/II Open-Label Study of Ipilimumab and GM-CSF Administered to Unresectable Stage IIIC and Stage IV Melanoma Patients | Unknown status |
| NCT03126916 | Phase III | Doxorubicin 131I-MIBG Sargramostim Etoposide Melphalan Busulfan Isotretinoin Vincristine Sulfate Cisplatin Cyclophosphamide Thiotepa Crizotinib Dexrazoxane Carboplatin Aldesleukin Topotecan Dinutuximab | Iobenguane I-131 or Crizotinib and Standard Therapy in Treating Younger Patients With Newly-Diagnosed High-Risk Neuroblastoma or Ganglioneuroblastoma | Recruiting |
| NCT01265433 | Phase II | Sargramostim WT1 vaccine | Randomized Study of Adjuvant WT-1 Analog Peptide Vaccine in Patients With Malignant Pleural Mesothelioma (MPM) After Completion of Combined Modality Therapy | Completed |
| NCT01827137 | Phase I | WT1 vaccine Lenalidomide Sargramostim | WT1 Analog Peptide Vaccine in Patients With Multiple Myeloma Following Autologous Stem Cell Transplantation | Active, not recruiting |
| NCT01479244 | Phase III | E75 Sargramostim | Efficacy and Safety Study of NeuVax (Nelipepimut-S or E75) Vaccine to Prevent Breast Cancer Recurrence | Completed |
| NCT03761914 | Phase Ib/II | Galinpepimut-S Galinpepimut-S + Pembrolizumab Pembrolizumab Sargramostim | Galinpepimut-S in Combination With Pembrolizumab in Patients With Selected Advanced Cancers | Recruiting |
| NCT01903330 | Phase II | Bevacizumab Cyclophosphamide Sargramostim | ERC1671/GM-CSF/Cyclophosphamide for the Treatment of Glioblastoma Multiforme | Recruiting |
| NCT01890980 | Phase II | WT1 vaccine Sargramostim | Phase II Study of Adjuvant WT-1 Analog Peptide Vaccine in MPM Patients After MSK10-134 | Completed |
| NCT01530984 | Phase II | Sargramostim Ipilimumab | Ipilimumab and GMCSF Immunotherapy for Prostate Cancer | Withdrawn |
| NCT02339571 | Phase II | Sargramostim Nivolumab Ipilimumab | Nivolumab and Ipilimumab With or Without Sargramostim in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery | Suspended |
| NCT00621036 | Phase II | Methotrexate Thiotepa Sargramostim | Vaccine Therapy and GM-CSF in Treating Patients With CNS Lymphoma | Withdrawn |
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