Drug Detail

Drug Name Tozasertib
Trade Name
Synonyms MK-0457|VX-680
Drug Descriptions

Tozasertib (VX-680) is a pan-AURK inhibitor with increased potency against Aurora kinase A (AURKA), and has additional activity against BCR-ABL, potentially resulting in decreased tumor growth (PMID: 14981513, PMID: 22772060).

DrugClasses AURK Inhibitor (Pan) 11 BCR-ABL Inhibitor 24

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Therapy Name Drugs Efficacy Evidence Clinical Trials
BIRB-796 + Tozasertib BIRB-796 Tozasertib 1 0
Doxorubicin + Tozasertib Doxorubicin Tozasertib 1 0
Tozasertib Tozasertib 1 0
Tozasertib + Venetoclax Tozasertib Venetoclax 0 0
Tozasertib + Vorinostat Tozasertib Vorinostat 0 0


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