Drug Detail


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Drug Name Prexasertib
Trade Name
Synonyms LY2606368|IC-83|ACR-368|ACR368|ACR 368
Drug Descriptions

Prexasertib (LY2606368) inhibits checkpoint kinase 1 (Chk1), which may result in accumulation of DNA damage and decreased tumor growth (PMID: 26141948, PMID: 28270495, PMID: 32539469, PMID: 32510664).

DrugClasses CHK1 Inhibitor 17
CAS Registry Number 1234015-52-1
NCIT ID C91392


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cetuximab + Prexasertib Cetuximab Prexasertib 0 1
Cetuximab + Prexasertib + Radiotherapy Cetuximab Prexasertib Radiotherapy 0 0
Cisplatin + Prexasertib Cisplatin Prexasertib 0 1
Cyclophosphamide + Prexasertib Cyclophosphamide Prexasertib 0 1
Cytarabine + Etoposide + Mitoxantrone + Prexasertib Cytarabine Etoposide Mitoxantrone Prexasertib 0 1
Cytarabine + Fludarabine + Prexasertib Cytarabine Fludarabine Prexasertib 0 1
Doxorubicin + Prexasertib Doxorubicin Prexasertib 0 0
Fluorouracil + Leucovorin + Prexasertib Fluorouracil Leucovorin Prexasertib 0 1
Gemcitabine + Prexasertib Gemcitabine Prexasertib 0 2
Irinotecan + Prexasertib Irinotecan Prexasertib 0 0
Irinotecan + Prexasertib + Temozolomide Irinotecan Prexasertib Temozolomide 0 1
LY3023414 + Prexasertib LY3023414 Prexasertib 1 1
LY3300054 + Prexasertib LY3300054 Prexasertib 0 1
Olaparib + Prexasertib Olaparib Prexasertib 0 1
Pemetrexed Disodium + Prexasertib Pemetrexed Disodium Prexasertib 0 1
Prexasertib Prexasertib 1 8
Prexasertib + Ralimetinib Prexasertib Ralimetinib 0 1

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